Heickell A G, Bellezza A J, Thompson H W, Burgoyne C F
LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans 70112, USA.
J Glaucoma. 2001 Oct;10(5):369-82. doi: 10.1097/00061198-200110000-00002.
To determine the effect of acute, experimentally increased intraocular pressure on deformation of the surface of the optic nerve head (optic nerve head surface compliance testing) in normal monkey eyes using confocal scanning laser tomography.
A total of 156 compliance tests were performed on 48 normal eyes of 30 monkeys in three separate studies. Compliance testing involved obtaining confocal scanning laser tomographic images using a 10 degrees and/or 15 degrees and/or 20 degrees scan angle at various times after intraocular pressure was raised from 10 to 30 or 45 mm Hg. At each point, six images were analyzed to provide a value for a parameter, called mean position of the disc, which was used to express the amount of deformation the surface of the optic nerve head had undergone at that point. Statistical analysis (ANOVA) was performed to evaluate differences in the amounts of deformation in individual eyes at different intraocular pressures and at different compliance testing sessions (studies 1 and 2) and in the two eyes of individual monkeys under the same conditions (study 3).
The majority of eyes showed posterior deformation of the surface of the optic nerve head ranging from 15 to 86 microm as early as 10 minutes after intraocular pressure was increased from 10 to 30 mm Hg. When pressure was increased from 30 to 45 mm Hg in a subset of these eyes, most showed additional deformation. Of the 12 eyes for which both 15 degrees and 20 degrees images were obtained at the same compliance test, 7 showed larger amounts of deformation in the 20 degrees images. Of the 18 monkeys tested in both eyes, 12 showed some differences and 4 showed substantial differences between the two eyes.
In the normal monkey eye, the surface of the optic nerve head deforms rapidly (in as few as 10 minutes) in response to increased intraocular pressure. The amount of deformation varies between subjects and even within the two eyes of individual monkeys. Increasing the scan angle from 15 degrees to 20 degrees frequently increases the amount of deformation detected, suggesting that the peripapillary sclera and the optic nerve head may be involved in the deformation in some eyes.
使用共焦扫描激光断层扫描技术，确定实验性急性眼压升高对正常猴眼视神经乳头表面变形（视神经乳头表面顺应性测试）的影响。
在三项独立研究中，对30只猴子的48只正常眼睛进行了总共156次顺应性测试。顺应性测试包括在眼压从10毫米汞柱升高到30或45毫米汞柱后的不同时间，使用10度和/或15度和/或20度扫描角度获取共焦扫描激光断层图像。在每个时间点，分析六张图像以得出一个名为视盘平均位置的参数值，该参数用于表示视神经乳头表面在该点所经历的变形量。进行统计分析（方差分析）以评估不同眼压下和不同顺应性测试阶段（研究1和2）时单眼的变形量差异，以及在相同条件下（研究3）个体猴子两只眼睛的变形量差异。
早在眼压从10毫米汞柱升高到30毫米汞柱后10分钟，大多数眼睛的视神经乳头表面就出现了15至86微米的后向变形。在这些眼睛中的一部分眼睛中，当压力从30毫米汞柱升高到45毫米汞柱时，大多数眼睛显示出额外的变形。在同一顺应性测试中同时获得15度和20度图像的12只眼睛中，7只在20度图像中显示出更大的变形量。在两只眼睛都接受测试的18只猴子中，12只两只眼睛之间存在一些差异，4只两只眼睛之间存在显著差异。
在正常猴眼中，视神经乳头表面会因眼压升高而迅速变形（短至10分钟）。变形量在不同个体之间甚至在个体猴子的两只眼睛之间都有所不同。将扫描角度从15度增加到20度通常会增加检测到的变形量，这表明在某些眼睛中，视乳头周围巩膜和视神经乳头可能参与了变形过程。
