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1
The role of calcium in insulin action. III. Calcium distribution in fat cells; its kinetics and the effects of adrenaline, insulin and procaine-HCl.钙在胰岛素作用中的角色。III. 钙在脂肪细胞中的分布；其动力学以及肾上腺素、胰岛素和盐酸普鲁卡因的影响。
Eur J Clin Invest. 1975 Jul 29;5(4):339-49. doi: 10.1111/j.1365-2362.1975.tb00463.x.
2
The role of calcium in insulin action. IV. Mechanism of insulin resistance in adipose tissue of obese (ob/ob) mice and old Wistar rats.钙在胰岛素作用中的角色。IV. 肥胖（ob/ob）小鼠和老年Wistar大鼠脂肪组织中胰岛素抵抗的机制。
Eur J Clin Invest. 1975 Jul 29;5(4):351-8. doi: 10.1111/j.1365-2362.1975.tb00464.x.
3
A kinetic analysis of the effects of adrenaline on calcium distribution in isolated rat liver parenchymal cells.肾上腺素对离体大鼠肝实质细胞钙分布影响的动力学分析。
J Physiol. 1981 Mar;312:29-55. doi: 10.1113/jphysiol.1981.sp013614.
4
Exchangeable and total calcium pools in mitochondria of rat epididymal fat-pads and isolated fat-cells. Role in the regulation of pyruvate dehydrogenase activity.大鼠附睾脂肪垫和分离脂肪细胞线粒体中的可交换钙池与总钙池。在丙酮酸脱氢酶活性调节中的作用。
Biochem J. 1976 Jan 15;154(1):209-23. doi: 10.1042/bj1540209.
5
Effects of insulin and procaine hydrochloride on glycogen synthetase activation and adipocyte calcium flux: evidence for a role of calcium in insulin activation of glycogen synthetase.胰岛素和盐酸普鲁卡因对糖原合成酶激活及脂肪细胞钙通量的影响：钙在胰岛素激活糖原合成酶中作用的证据
Horm Metab Res. 1976 May;8(3):184-90. doi: 10.1055/s-0028-1093657.
6
Calcium release from membrane-bound calcium pool induced by ACTH.促肾上腺皮质激素诱导的膜结合钙池钙释放。
Int J Clin Pharmacol Ther Toxicol. 1982 May;20(5):209-11.
7
Is insulin's second messenger calcium?胰岛素的第二信使是钙吗？
Proc R Soc Med. 1975 Dec;68(12):785-91. doi: 10.1177/003591577506801226.
8
The stimulating effect of 3',5'-(cyclic)adenosine monophosphate and lipolytic hormones on 3-O-methylglucose transport and 45Ca2+ release in adipocytes and skeletal muscle of the rat.3',5' -（环）磷酸腺苷和脂解激素对大鼠脂肪细胞和骨骼肌中3 - O - 甲基葡萄糖转运及45Ca2+释放的刺激作用。
Biochim Biophys Acta. 1982 Dec 22;693(2):389-97. doi: 10.1016/0005-2736(82)90446-1.
9
Relationships between the exchange of calcium and phosphate in isolated fat-cells.分离脂肪细胞中钙与磷酸盐交换的关系。
Biochem J. 1975 Oct;152(1):121-9. doi: 10.1042/bj1520121.
10
The relationship between the transport of glucose and cations across cell membranes in isolated tissues. X. Effect of glucose transport stimuli on the efflux of isotopically labelled calcium and 3-O-methylglucose from soleus muscles and epididymal fat pads of the rat.分离组织中葡萄糖与阳离子跨细胞膜转运的关系。X. 葡萄糖转运刺激对大鼠比目鱼肌和附睾脂肪垫中同位素标记钙及3 - O - 甲基葡萄糖外流的影响。
Biochim Biophys Acta. 1980 Nov 4;602(2):433-45. doi: 10.1016/0005-2736(80)90322-3.

引用本文的文献

1
Alteration of the intracellular calcium pool of adipose tissue in spontaneously hypertensive rats. No effect of peripheral immunosympathectomy.自发性高血压大鼠脂肪组织细胞内钙库的改变。外周免疫交感神经切除术无影响。
Pflugers Arch. 1981 Jun;390(3):256-9. doi: 10.1007/BF00658271.
2
Alteration of intracellular calcium distribution in the adipose tissue of patients with essential hypertension.原发性高血压患者脂肪组织中细胞内钙分布的改变。
Pflugers Arch. 1980 Oct;388(1):89-91. doi: 10.1007/BF00582634.
3
The effect of insulin on plasma-membrane and mitochondrial-membrane potentials in isolated fat-cells.胰岛素对分离脂肪细胞的质膜电位和线粒体膜电位的影响。
Biochem J. 1981 Apr 15;196(1):133-47. doi: 10.1042/bj1960133.
4
Parathyroid hormone and calcitonin in glucose regulation.甲状旁腺激素与降钙素在葡萄糖调节中的作用
Eur J Pediatr. 1980 Dec;135(2):195-8. doi: 10.1007/BF00441641.
5
Insulin and glucose 6-phosphate stimulation of Ca2+ uptake by skinned muscle fibers.胰岛素和6-磷酸葡萄糖对去表皮肌纤维摄取钙离子的刺激作用。
Proc Natl Acad Sci U S A. 1980 Feb;77(2):936-9. doi: 10.1073/pnas.77.2.936.
6
Calcium-dependence of insulin receptor phosphorylation.胰岛素受体磷酸化的钙依赖性。
Biochem J. 1983 Aug 15;214(2):361-6. doi: 10.1042/bj2140361.
7
A partial view of the mechanism of insulin action.胰岛素作用机制的部分观点。
Diabetologia. 1981 Oct;21(4):347-62. doi: 10.1007/BF00252681.
8
Features of adipocyte sensitivity to lipolytic agents in spontaneously hypertensive rats. Possible role of altered intracellular calcium distribution.自发性高血压大鼠脂肪细胞对脂解剂的敏感性特征。细胞内钙分布改变的可能作用。
Pflugers Arch. 1980 Mar;384(2):183-8. doi: 10.1007/BF00584437.
9
Ability of insulin to increase calcium binding by adipocyte plasma membranes.胰岛素增强脂肪细胞质膜钙结合的能力。
Proc Natl Acad Sci U S A. 1976 May;73(5):1542-6. doi: 10.1073/pnas.73.5.1542.
10
The effect of insulin on the washout of [45Ca]calcium from adipocytes and soleus muscle of the rat.胰岛素对大鼠脂肪细胞和比目鱼肌中[45Ca]钙洗脱的影响。
Biochem J. 1977 Apr 15;164(1):251-5. doi: 10.1042/bj1640251.

钙在胰岛素作用中的角色。III. 钙在脂肪细胞中的分布；其动力学以及肾上腺素、胰岛素和盐酸普鲁卡因的影响。

The role of calcium in insulin action. III. Calcium distribution in fat cells; its kinetics and the effects of adrenaline, insulin and procaine-HCl.

作者信息

Kissebah A H, Clarke P, Vydelingum N, Hope-Gill H, Tulloch B, Fraser T R

出版信息

Eur J Clin Invest. 1975 Jul 29;5(4):339-49. doi: 10.1111/j.1365-2362.1975.tb00463.x.

DOI:10.1111/j.1365-2362.1975.tb00463.x
PMID:1175673
Abstract

The effects of adrenaline, insulin and procaine-HCl on Ca distribution in intact fat cells and on Ca binding to fat cell ghost membranes have been investigated. 1. Fat cells incubated in 45Ca containing media till isotopic equilibrium indicated that the exchangeable Ca in these cells averages 25.7 +/-3.2nmol/mg protein, which represents approximately 9.8% of their ttotal Ca content. 2. Perifusion of 45Ca prelabelled fat cells gave washout curves whose analysis conformed with three kinetically distinct Ca pools (Fig. 1). The fast exchangeable pool (Compartment A) had an efflux rate constant of 0.193 +/-0. 013 min.-. The release of Ca from the second and thrid pools (Compartments B and C) was much slower with efflux rate constants of 0.032 +/-0.0018 min.-1 and 0.0042 +/- 0.0006 min.-1 respectively. Changing the Ca concentration in the perifusing medium modified the initial fast phase and its rate constant, while added dinitrophenol (DNP) inhibited the efflux rate from the later compartments...

摘要

研究了肾上腺素、胰岛素和盐酸普鲁卡因对完整脂肪细胞中钙分布以及钙与脂肪细胞质膜结合的影响。1. 在含45Ca的培养基中孵育脂肪细胞直至达到同位素平衡，结果表明这些细胞中可交换钙的平均含量为25.7±3.2nmol/mg蛋白质，约占其总钙含量的9.8%。2. 对预先用45Ca标记的脂肪细胞进行灌流，得到的洗脱曲线分析显示存在三个动力学上不同的钙池（图1）。快速可交换池（A区室）的流出速率常数为0.193±0.013min-1。钙从第二和第三池（B区室和C区室）的释放要慢得多，流出速率常数分别为0.032±0.0018min-1和0.0042±0.0006min-1。改变灌流培养基中的钙浓度会改变初始快速阶段及其速率常数，而添加二硝基苯酚（DNP）会抑制后期区室的流出速率……