Henderson T R, Hamosh M, Armand M, Mehta N R, Hamosh P
Department of Pediatrics, Georgetown University Medical Center, Washington, DC, USA.
Adv Exp Med Biol. 2001;501:403-8. doi: 10.1007/978-1-4615-1371-1_50.
Gastric proteolysis is assumed to be low in the newborn (Britton & Koldovsky 1989). Postprandial pepsin output is significantly lower in preterm infants than adults, 589 vs. 3352U/kg, respectively (Armand et al. 1995, 1996). We now report on gastric proteolysis in preterm infants (gestation age, 29 weeks; postnatal age, 5-6 weeks) gavage-fed mother's milk or preemie formula. The data show that a) the nonprotein component is higher in human milk than formula, b) net proteolysis amounts to 15% of protein, c) gastric proteolysis is lower than lipolysis and, contrary to the latter, is not enhanced by milk feeding (Armand et al. 1996). We suggest that stomach pH, enzyme output, and food structure are the reasons for differences in gastric digestion of protein and fat in infants.
一般认为新生儿的胃蛋白水解作用较弱（布里顿和科尔多夫斯基，1989年）。早产儿餐后胃蛋白酶的分泌量显著低于成年人，分别为589U/kg和3352U/kg（阿曼德等人，1995年、1996年）。我们现在报告对胎龄29周、出生后5 - 6周的早产儿进行管饲母乳或早产儿配方奶时的胃蛋白水解情况。数据显示：a）母乳中的非蛋白质成分高于配方奶；b）净蛋白水解量占蛋白质的15%；c）胃蛋白水解作用低于脂肪水解作用，而且与脂肪水解作用不同的是，喂奶并不会增强胃蛋白水解作用（阿曼德等人，1996年）。我们认为胃内pH值、酶分泌量和食物结构是造成婴儿胃内蛋白质和脂肪消化差异的原因。
