Piérard-Franchimont C, Piérard G E
Department of Dermatopathology, University Medical Center Sart Tilman, Liège, Belgium.
Dermatology. 2002;204(1):17-22. doi: 10.1159/000051804.
The endocrine control of sebaceous follicles is complex in women. During aging, a decline in sebum output is often experienced. However, some women report increased seborrhea after the menopause.
In this study, the follicular reservoir function was studied during the first decade following the menopause.
Four evaluations were made at 3-week intervals in two parallel age-matched groups of 50 postmenopausal women receiving hormone replacement therapy (HRT) or not. The Sebumeter served to measure the casual sebum level and the sebum excretion rate on the forehead. In addition, a Visioscan equipped with an ultraviolet-recording camera was used with and without lipid-sensitive tapes interposed between the camera and the skin surface. Follicular openings and sebum pore patterns were studied by image analysis.
There was enormous diversity among individual values of sebum output at the skin surface. In untreated women, a significant decline in sebum excretion rate accompanied by an increase in both the sebum replacement time and the mean pore size were evidenced during the first decade after the menopause. The sebum excretion rate and casual level showed a wide range of interindividual differences early after the menopause. These physiological changes were less prominent in women receiving HRT.
Postmenopausal aging affects the sebum production, but HRT does not significantly control the complex process of seborrhea. However, HRT mitigates the progressive enlargement of the openings of the sebum follicular reservoir.
女性皮脂腺毛囊的内分泌控制较为复杂。在衰老过程中，皮脂分泌量常出现下降。然而，一些女性在绝经后报告脂溢现象有所增加。
在本研究中，对绝经后第一个十年期间的毛囊储脂功能进行了研究。
对两组各50名年龄匹配的绝经后女性进行了平行研究，一组接受激素替代疗法（HRT），另一组未接受，每3周进行一次四项评估。使用皮脂仪测量前额的随机皮脂水平和皮脂排泄率。此外，使用配备紫外线记录相机的Visioscan，在相机与皮肤表面之间插入或不插入脂质敏感胶带。通过图像分析研究毛囊开口和皮脂孔模式。
皮肤表面皮脂分泌量的个体值差异极大。在未接受治疗的女性中，绝经后的第一个十年期间，皮脂排泄率显著下降，同时皮脂更新时间和平均孔径均增加。绝经后早期，皮脂排泄率和随机水平显示出广泛的个体间差异。这些生理变化在接受HRT的女性中不太明显。
绝经后衰老会影响皮脂生成，但HRT并不能显著控制脂溢的复杂过程。然而，HRT可减轻皮脂毛囊储脂开口的逐渐扩大。
