更年期激素替代疗法对皮肤力学性能的影响。
Effect of hormone replacement therapy for menopause on the mechanical properties of skin.
作者信息
Piérard G E, Letawe C, Dowlati A, Piérard-Franchimont C
机构信息
Department of Dermatopathology, CHU Sart Tilman, University of Liège, Belgium.
出版信息
J Am Geriatr Soc. 1995 Jun;43(6):662-5. doi: 10.1111/j.1532-5415.1995.tb07202.x.
OBJECTIVE
To evaluate the effect of hormone replacement therapy (HRT) for menopause on the mechanical properties of the skin in healthy women.
DESIGN
A group of 114 women, including 43 nonmenopausal controls, 46 menopausal women with HRT and 25 menopausal women without HRT, participated in the study. Mechanical properties of the skin were measured on the volar forearm using a computerized suction device.
SETTING
University medical center. Research laboratory in bioengineering and biometrology.
RESULTS
Computerized measurements of skin deformability and viscoelasticity revealed differences between the three groups of women. A steep increase in skin extensibility was evidenced during the perimenopause in untreated women. HRT appeared to limit the age-related increase in cutaneous extensibility, thereby exerting a preventive effect on skin slackness. No effect of HRT was found on other parameters of skin viscoelasticity.
CONCLUSION
HRT has a beneficial effect on some mechanical properties of skin and thus may slow the progress of intrinsic cutaneous aging.
目的
评估绝经后激素替代疗法（HRT）对健康女性皮肤力学性能的影响。
设计
114名女性参与了该研究，其中包括43名未绝经的对照者、46名接受HRT的绝经女性和25名未接受HRT的绝经女性。使用计算机化吸力装置在前臂掌侧测量皮肤的力学性能。
地点
大学医学中心。生物工程与生物计量学研究实验室。
结果
对皮肤可变形性和粘弹性的计算机化测量显示，三组女性之间存在差异。未经治疗的女性在围绝经期皮肤伸展性急剧增加。HRT似乎限制了与年龄相关的皮肤伸展性增加，从而对皮肤松弛起到预防作用。未发现HRT对皮肤粘弹性的其他参数有影响。
结论
HRT对皮肤的某些力学性能有有益影响，因此可能会减缓皮肤内在老化的进程。
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