Appleton D J, Rand J S, Sunvold G D, Priest J
Companion Animal Sciences Department, School of Veterinary Science and Animal Production, The University of Queensland, St. Lucia, Brisbane, Qld, 4072, Australia.
J Feline Med Surg. 2002 Mar;4(1):13-25. doi: 10.1053/jfms.2001.0157.
The effect of dietary chromium supplementation on glucose and insulin metabolism in healthy, non-obese cats was evaluated. Thirty-two cats were randomly divided into four groups and fed experimental diets consisting of a standard diet with 0 ppb (control), 150 ppb, 300 ppb, or 600 ppb added chromium as chromium tripicolinate. Intravenous glucose tolerance, insulin tolerance and insulin sensitivity tests with minimal model analysis were performed before and after 6 weeks of feeding the test diets. During the glucose tolerance test, glucose concentrations, area under the glucose concentration-time curve, and glucose half-life (300 ppb only), were significantly lower after the trial in cats supplemented with 300 ppb and 600 ppb chromium, compared with values before the trial. Fasting glucose concentrations measured on a different day in the biochemistry profile were also significantly lower after supplementation with 600 ppb chromium. There were no significant differences in insulin concentrations or indices in either the glucose or insulin tolerance tests following chromium supplementation, nor were there any differences between groups before or after the dietary trial.Importantly, this study has shown a small but significant, dose-dependent improvement in glucose tolerance in healthy, non-obese cats supplemented with dietary chromium. Further long-term studies are warranted to determine if the addition of chromium to feline diets is advantageous. Cats most likely to benefit are those with glucose intolerance and insulin resistance from lack of exercise, obesity and old age. Healthy cats at risk of glucose intolerance and diabetes from underlying low insulin sensitivity or genetic factors may also benefit from long-term chromium supplementation.
评估了膳食补充铬对健康、非肥胖猫的葡萄糖和胰岛素代谢的影响。32只猫被随机分为四组，分别喂食添加了0 ppb（对照组）、150 ppb、300 ppb或600 ppb吡啶羧酸铬的标准饮食作为实验性饮食。在喂食试验饮食6周前后，进行了静脉葡萄糖耐量、胰岛素耐量和胰岛素敏感性测试，并采用最小模型分析。在葡萄糖耐量试验期间，与试验前的值相比，补充300 ppb和600 ppb铬的猫在试验后葡萄糖浓度、葡萄糖浓度-时间曲线下面积和葡萄糖半衰期（仅300 ppb组）显著降低。在生化指标中，在不同日期测量的空腹葡萄糖浓度在补充600 ppb铬后也显著降低。补充铬后，在葡萄糖或胰岛素耐量试验中胰岛素浓度或指标均无显著差异，饮食试验前后各组之间也无差异。重要的是，这项研究表明，在健康、非肥胖的猫中，膳食补充铬可使葡萄糖耐量有小但显著的剂量依赖性改善。有必要进行进一步的长期研究，以确定在猫的饮食中添加铬是否有益。最可能受益的猫是那些因缺乏运动、肥胖和年老而患有葡萄糖不耐受和胰岛素抵抗的猫。因潜在的低胰岛素敏感性或遗传因素而有葡萄糖不耐受和糖尿病风险的健康猫也可能从长期补充铬中受益。
