Montgomery Johanna M, Madison Daniel V
Department of Molecular and Cellular Physiology, Beckman Center, Stanford University School of Medicine, CA 94305, USA.
Neuron. 2002 Feb 28;33(5):765-77. doi: 10.1016/s0896-6273(02)00606-2.
Paired recordings between CA3 pyramidal neurons were used to study the properties of synaptic plasticity in active and silent synapses. Synaptic depression is accompanied by decreases in both AMPAR and NMDAR function. The mechanisms of synaptic depression, and the potential to undergo activity-dependent plastic changes in efficacy, differ depending on whether a synapse is active, recently silent, or potentiated. These results suggest that silent and active synapses represent distinct synaptic "states," and that once unsilenced, synapses express plasticity in a graded manner. The state in which a synapse resides, and the states recently visited, determine its potential and mechanism for undergoing subsequent plastic changes.
使用CA3锥体神经元之间的配对记录来研究活跃和沉默突触中突触可塑性的特性。突触抑制伴随着AMPA受体和NMDA受体功能的降低。突触抑制的机制以及在效能上经历活动依赖性可塑性变化的潜力，取决于突触是活跃的、最近沉默的还是增强的。这些结果表明，沉默突触和活跃突触代表不同的突触“状态”，并且一旦解除沉默，突触就会以分级方式表达可塑性。突触所处的状态以及最近经历的状态，决定了其经历后续可塑性变化的潜力和机制。
