口服耐受与针对膳食蛋白质的肠道免疫反应。

Oral tolerance and gut-oriented immune response to dietary proteins.

作者信息

Alpan O

机构信息

Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 111, 9000 Rockville Pike, Bethesda, MD 20850, USA.

出版信息

Curr Allergy Asthma Rep. 2001 Nov;1(6):572-7. doi: 10.1007/s11882-001-0067-6.

DOI:10.1007/s11882-001-0067-6

PMID:11892087

Abstract

Dietary proteins induce both a local immune response characterized by IgA production and systemic immune response characterized by the production of TH2/TH3 cytokines. By influencing the class of immune response, the gut enhances the efficacy of immunity against proteins that enter the body through the diet while, at the same time, ensuring its own safety. This article reviews and summarizes the field of "oral tolerance," with emphasis on recent advancements.

摘要

膳食蛋白质可诱导以IgA产生为特征的局部免疫反应和以TH2/TH3细胞因子产生为特征的全身免疫反应。通过影响免疫反应的类型，肠道增强了针对通过饮食进入体内的蛋白质的免疫效力，同时确保自身安全。本文回顾并总结了“口服耐受”领域，重点介绍了近期的进展。