Gruys E
Vet Pathol. 1975;12(2):94-110. doi: 10.1177/030098587501200202.
Electron micrsocopic studies of bovine kidneys with amyloidosis showed macrophage-like cells in the interstitial amyloid that were either disseminated or in small groups. They had rather uniform protracted vacuoles filled with parallel fibrils. Similar vacuoles were also found in some reticular interstitial cells. In some samples electron-dense vacuoles and vacuoles containing fibrils were seen. Protracted lysosomal enzyme activity was seen in macrophage-like cells and reticular interstitial cells; these areas of activity showed green birefringence with Congo red. The vacuoles were thought to be lysosomes, and the parallel amyloid fibrils could be a consequence of intracellular formation or of phagocytosis.
对患淀粉样变性的牛肾脏进行的电子显微镜研究显示，间质淀粉样物质中有散在分布或成小群的巨噬细胞样细胞。它们有相当均匀的细长空泡，里面充满平行的原纤维。在一些网状间质细胞中也发现了类似的空泡。在一些样本中可见电子致密空泡和含原纤维的空泡。在巨噬细胞样细胞和网状间质细胞中可见持久的溶酶体酶活性；这些活性区域用刚果红染色显示绿色双折射。这些空泡被认为是溶酶体，平行的淀粉样原纤维可能是细胞内形成或吞噬作用的结果。
