Gruys E, Timmermans H J, van Ederen A M
Lab Anim. 1979 Jan;13(1):1-9. doi: 10.1258/002367779781071230.
In induced amyloidosis the amyloid was first deposited in the portal areas, then in the centre of the lobule and disseminated through it in the spaces of Disse. No intracellular amyloid was found in the predeposit phase. In the hepatic lobule both mononuclear phagocytes and hepatocytes showed a topographic relationship to the first deposits of amyloid. Some macrophages showed invaginations or vacuoles containing amyloid fibrils. Between the microvilli of hepatocytes, parallel amyloid fibrils occurred. Between the amyloid fibrils were 30-50 nm membrane-bounded spherical particles which may have been lipoprotein aggregates. There was no large-scale phagocytosis of amyloid during the induction period or after survival without casein treatment up to 18 weeks. Lysosomal enzyme activity was seen in the deposits of extracellular amyloid.
在诱导性淀粉样变性中，淀粉样物质首先沉积于汇管区，然后在肝小叶中央，并通过狄氏间隙在肝小叶内播散。在预沉积阶段未发现细胞内淀粉样物质。在肝小叶中，单核吞噬细胞和肝细胞均与淀粉样物质的首次沉积存在拓扑学关系。一些巨噬细胞出现含有淀粉样纤维的内陷或空泡。在肝细胞微绒毛之间出现平行的淀粉样纤维。在淀粉样纤维之间有30 - 50纳米的膜包被球形颗粒，可能是脂蛋白聚集体。在诱导期或未经酪蛋白处理存活长达18周后，均未出现淀粉样物质的大规模吞噬现象。在细胞外淀粉样物质沉积物中可见溶酶体酶活性。
