Carruth Marc R, Goldstein Glenn D, Tillman Donald K
Skin and Mohs Surgery Center, Kansas City, Missouri, USA.
Dermatol Surg. 2002 Mar;28(3):241-3. doi: 10.1046/j.1524-4725.2002.01139.x.
Melanosis is a rare, but well recognized late complication of some cases of metastatic melanoma. The precise pathogenesis is unclear. Most described cases report diffuse metastases and diffuse melanosis.
To present a case of localized melanosis secondary to locally metastatic melanoma without evidence of systemic involvement in a renal transplant patient.
Case report and literature review.
We describe a case of localized melanosis in an immunocompromised patient without evidence of systemic metastases. The patient underwent limb perfusion and her immunosuppressive therapy has been stopped. The melanosis has not regressed; however, there has been no systemic involvement and her transplanted kidney is still functioning well.
To our knowledge this is the first report of this phenomenon in an immunocompromised host.
黑色素沉着是某些转移性黑色素瘤病例中一种罕见但已被充分认识的晚期并发症。确切的发病机制尚不清楚。大多数已描述的病例报告有弥漫性转移和弥漫性黑色素沉着。
报告一例肾移植患者发生局部转移性黑色素瘤继发局部黑色素沉着且无全身受累证据的病例。
病例报告及文献复习。
我们描述了一例免疫功能低下患者发生局部黑色素沉着且无全身转移证据的病例。该患者接受了肢体灌注治疗，其免疫抑制治疗已停止。黑色素沉着未消退；然而，尚无全身受累情况，且其移植肾仍功能良好。
据我们所知，这是免疫功能低下宿主中该现象的首例报告。
