Adrian R M, Murphy G F, Sato S, Granstein R D, Fitzpatrick T B, Sober A J
J Am Acad Dermatol. 1981 Sep;5(3):308-18. doi: 10.1016/s0190-9622(81)70097-5.
Tumor-free hyperpigmented skin from a patient with diffuse melanosis secondary to metastatic melanoma was examined by light and electron microscopy. Our findings indicate that the pathogenesis of this diffuse slate blue color is primarily to pigment deposition within perivascular dermal macrophages. We did not find intact melanosomes or individual tumor cell metastases in clinically normal skin, as has been previously reported.
对一名因转移性黑色素瘤继发弥漫性黑变病患者的无肿瘤色素沉着皮肤进行了光镜和电镜检查。我们的研究结果表明，这种弥漫性石板蓝色的发病机制主要是血管周围真皮巨噬细胞内的色素沉积。与之前报道的情况不同，我们在临床正常皮肤中未发现完整的黑素小体或单个肿瘤细胞转移灶。
