Grant S, MacLeod N, Kay J W, Watt M, Patel S, Paterson A, Peacock A
Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK.
Br J Sports Med. 2002 Apr;36(2):141-6. doi: 10.1136/bjsm.36.2.141.
To compare a range of physiological responses to acute sea level hypoxia at simulated altitudes with the same physiological responses and acute mountain sickness (AMS) scores measured at altitude (similar to the simulated altitudes) during a 17 day trek in the Himalayas.
Twenty men and women aged 18-54 years took part in the study. End tidal CO(2) tension (PETCO(2)) and saturated oxygen (SaO(2)) were measured using a capnograph. Observations made at sea level and some simulated altitudes were compared with those in the Himalayas. Pairwise correlations were used to examine the correlation between variables and regression, with 95% prediction intervals providing information on how well one variable could be predicted from another for a given subject.
There was only a significant correlation for a few comparisons. The 95% prediction intervals for individual SaO(2) values at a range of simulated altitudes were fairly wide going from +/- 4% to +/- 5%. All of the correlations between laboratory and Himalayan PETCO(2) values were not statistically significant. There was a significant correlation for the relation between SaO(2)and PETCO(2) at sea level for the laboratory data (r=-0.51; p=0.05). For the Himalayan data, there were significant correlations at Namche Bazaar (3450 m; day 3) (r=-0.56; p=0.01) and Dingboche (4300 m; day 6) (r=-0.48; p=0.03). The correlation between SaO(2) and PETCO(2) and AMS was generally poor.
The results indicate that limited information can be gained on a subject's response to altitude by assessing physiological variables at sea level and a range of simulated altitudes before the subject carries out a trek at altitude.
比较一系列在模拟海拔高度下对急性海平面缺氧的生理反应，以及在喜马拉雅山为期17天的徒步旅行中，在海拔高度（类似于模拟海拔高度）测得的相同生理反应和急性高山病（AMS）评分。
20名年龄在18 - 54岁之间的男性和女性参与了该研究。使用二氧化碳分析仪测量呼气末二氧化碳分压（PETCO₂）和血氧饱和度（SaO₂）。将在海平面和一些模拟海拔高度下的观测结果与在喜马拉雅山的观测结果进行比较。使用成对相关性来检验变量之间的相关性以及回归情况，95%预测区间提供了关于给定受试者一个变量能从另一个变量预测得有多好的信息。
只有少数比较存在显著相关性。在一系列模拟海拔高度下，个体SaO₂值的95%预测区间相当宽，从±4%到±5%。实验室和喜马拉雅山PETCO₂值之间的所有相关性均无统计学意义。对于实验室数据，海平面上SaO₂与PETCO₂之间的关系存在显著相关性（r = -0.51；p = 0.05）。对于喜马拉雅山的数据，在南池市场（3450米；第3天）（r = -0.56；p = 0.01）和丁波切（4300米；第6天）（r = -0.48；p = 0.03）存在显著相关性。SaO₂与PETCO₂和AMS之间的相关性总体较差。
结果表明，在受试者进行海拔徒步旅行之前，通过评估海平面和一系列模拟海拔高度下的生理变量，关于受试者对海拔高度反应的信息获取有限。
