Sellebjerg F, Giovannoni G, Hand A, Madsen H O, Jensen C V, Garred P
Department of Neurology, University of Copenhagen, Glostrup Hospital, Nordre Ringvej 57, DK-2600 Glostrup Copenhagen, Denmark.
J Neuroimmunol. 2002 Apr;125(1-2):198-203. doi: 10.1016/s0165-5728(02)00037-1.
The role of nitric oxide (NO) in multiple sclerosis (MS) is not clear. We found increased cerebrospinal fluid concentrations of the NO degradation products nitrate (NO(x)) in clinically definite MS but not in clinically isolated syndromes. High CSF concentrations of NO(x) correlated with long attack duration. Patients carrying the truncated CC chemokine receptor allele CCR5 Delta32 had lower serum concentration of NO(x) at later attack stages. NO(x) concentrations did not change after methylprednisolone treatment but high concentrations were associated with more pronounced treatment responses. These findings suggest an association of high CSF levels of NO(x) with more severe disease activity in relapsing-remitting MS.
一氧化氮（NO）在多发性硬化症（MS）中的作用尚不清楚。我们发现，在临床确诊的MS患者中，脑脊液中NO降解产物硝酸盐（NO(x)）的浓度升高，而在临床孤立综合征患者中则未升高。脑脊液中高浓度的NO(x)与发作持续时间长相关。携带截短型CC趋化因子受体等位基因CCR5 Delta32的患者在发作后期血清中NO(x)浓度较低。甲基强的松龙治疗后NO(x)浓度没有变化，但高浓度与更明显的治疗反应相关。这些发现表明，脑脊液中高浓度的NO(x)与复发缓解型MS中更严重的疾病活动有关。
