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小肠结肠炎耶尔森菌蛋白质和脂多糖的抗原性

Antigenicity of protein and lipopolysaccharide from Yersinia enterocolitica.

作者信息

Ogata S, Kanamori M, Miyashita K

出版信息

Contrib Microbiol Immunol. 1979;5:64-72.

PMID:119613
Abstract

The rabbits infected intravenously with viable Yersinia enterocolitica (Y.e.) produced the precipitating antibodies against a protein component as well as lipopolysaccharide of the organism. The production of the precipitins against protein antigen persisted for a long period of time even after the O-agglutinins had disappeared. The rabbits infected orally with the organism produced only the precipitins against protein antigen, and the amount of the antibody was equal to or greater than that of intravenous infection. The same precipitins that rabbits produced were detected even in human patients with yersiniosis showing O-agglutinin titers as low as less than or equal to 1:20. The antibody titers of mice infected with Y.e. were markedly lower than those of rabbits.

摘要

经静脉注射活的小肠结肠炎耶尔森菌(Y.e.)的兔子,产生了针对该菌一种蛋白质成分以及脂多糖的沉淀抗体。即使O凝集素消失后,针对蛋白质抗原的沉淀素仍能长时间产生。经口服该菌感染的兔子仅产生针对蛋白质抗原的沉淀素,且抗体量等于或大于静脉感染的情况。在小肠结肠炎耶尔森菌病患者中,即使O凝集素效价低至小于或等于1:20,也能检测到兔子所产生的相同沉淀素。感染Y.e.的小鼠的抗体效价明显低于兔子。

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