Sackett Catherine Stewart, Schenning Sherrie
Wilmer Institute Woods, 265 600 North Wolfe Street, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
Insight. 2002 Jan-Mar;27(1):5-7.
The Age-Related Eye Disease Study (AREDS) is a multi-center study sponsored by the National Eye Institute to determine the natural history and risk factors associated with both cataract and age-related macular degeneration (AMD). AREDS incorporated a clinical trial to determine what role micro nutrients may play in the development and progression of cataracts and AMD. The micro nutrients studied were the antioxidants vitamins E,C, beta-carotene and zinc with copper. Participants were randomized to either antioxidants, mineral, a combination of antioxidants and minerals or placebo. The participants were categorized, by the presence of drusen and diagnosis of AMD into one of four groups: no AMD, early AMD, intermediate AMD or advanced AMD. They were followed for an average of 6.3 years. There was no statistically significant difference in the cataract trial between treatment and placebo. In the AMD trial groups, those at high risk of developing advanced AMD lowered their risk by about 25% when treated with the mega dosages of the combination of antioxidants and minerals.
年龄相关性眼病研究（AREDS）是一项由美国国立眼科研究所资助的多中心研究，旨在确定与白内障和年龄相关性黄斑变性（AMD）相关的自然病史和风险因素。AREDS纳入了一项临床试验，以确定微量营养素在白内障和AMD的发生和发展中可能发挥的作用。所研究的微量营养素是抗氧化剂维生素E、C、β-胡萝卜素以及含铜的锌。参与者被随机分为抗氧化剂组、矿物质组、抗氧化剂与矿物质组合组或安慰剂组。参与者根据是否存在玻璃膜疣以及AMD的诊断被分为四组之一：无AMD、早期AMD、中期AMD或晚期AMD。他们平均随访了6.3年。在白内障试验中，治疗组和安慰剂组之间没有统计学上的显著差异。在AMD试验组中，那些有发展为晚期AMD高风险的人在接受大剂量抗氧化剂和矿物质组合治疗时，其风险降低了约25%。
