黑腹果蝇 rosy 区域的自发不等交换
Spontaneous unequal exchange in the rosy region of Drosophila melanogaster.
作者信息
Gelbart W M, Chovnick A
出版信息
Genetics. 1979 Jul;92(3):849-59. doi: 10.1093/genetics/92.3.849.
Abstract
A selective system for recovery of exchanges between trans mutations at adjacent loci, l(3)S12 and rosy, is described. In addition to the expected crossover and conversion classes, two exceptional types of offspring were recovered. Triploid offspring arose as 0.01% of all zygotes; the diploid chromosome set was apparently of maternal origin. Nine tandem duplications derived from unequal exchange between nonsister homologues were recovered among 2.25 x 10(6) zygotes screened. From considerations of the proportion of the genome that was assayed in this system, and on the assumption that the rate of unequal exchange observed is typical for the genome as a whole, it appears that one unequal exchange occurs per 500 female meioses in Drosophila.
摘要
本文描述了一种用于恢复相邻基因座l(3)S12和玫瑰色基因座间反式突变交换的选择系统。除了预期的交换和转换类型外，还获得了两种特殊类型的后代。三倍体后代占所有合子的0.01%；其二倍体染色体组显然来自母本。在筛选的2.25×10⁶个合子中，发现了9个由非姐妹同源染色体间不等交换产生的串联重复。从该系统中所检测基因组比例的角度考虑，并假设所观察到的不等交换率对整个基因组具有代表性，似乎在果蝇中每500次雌性减数分裂就会发生一次不等交换。
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