Pashenkov M, Teleshova N, Kouwenhoven M, Kostulas V, Huang Y-M, Soderstrom M, Link H
Division of Neurology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden.
Clin Exp Immunol. 2002 Mar;127(3):519-26. doi: 10.1046/j.1365-2249.2002.01779.x.
Myeloid and plasmacytoid dendritic cells (DC) are present in cerebrospinal fluid (CSF) in non-inflammatory neurological diseases (NIND) and elevated in clinically definite multiple sclerosis (MS) and in early MS - acute monosymptomatic optic neuritis (ON). Here, we show that expression of CCR5, a chemokine receptor for regulated on activation, normal T cell expressed and secreted (RANTES) and macrophage inflammatory protein (MIP)-1alpha/beta, is elevated on blood myeloid (CD11c+) DC in MS and ON compared to non-inflammatory controls. In contrast, expression of CXCR4, a receptor for stromal cell-derived factor (SDF)-1alpha, is similar in all groups. Blood myeloid DC from MS patients respond chemotactically to RANTES and MIP-1beta, which are expessed in MS lesions. In active MS and ON, expression of CCR5 by myeloid DC in blood correlates with numbers of these cells in CSF. Thus, elevation of CCR5 may contribute to recruitment of myeloid DC to CSF in MS and ON. Recruitment of plasmacytoid DC to CSF appears to be CCR5-independent.
髓样和浆细胞样树突状细胞（DC）存在于非炎性神经系统疾病（NIND）的脑脊液（CSF）中，在临床确诊的多发性硬化症（MS）以及早期MS - 急性单症状性视神经炎（ON）中数量升高。在此，我们表明，与非炎性对照相比，MS和ON患者血液中的髓样（CD11c +）DC上CCR5的表达升高，CCR5是一种趋化因子受体，可调节活化正常T细胞表达和分泌（RANTES）以及巨噬细胞炎性蛋白（MIP）-1α/β。相比之下，基质细胞衍生因子（SDF）-1α的受体CXCR4在所有组中的表达相似。来自MS患者的血液髓样DC对MS病变中表达的RANTES和MIP-1β产生趋化反应。在活动性MS和ON中，血液中髓样DC的CCR5表达与CSF中这些细胞的数量相关。因此，CCR5的升高可能有助于MS和ON中髓样DC募集到CSF中。浆细胞样DC募集到CSF似乎与CCR5无关。
