Gillam D G, Tang J Y, Mordan N J, Newman H N
Department of Periodontology, Eastman Dental Institute for Oral Health Care Sciences, University College London, London, UK.
J Oral Rehabil. 2002 Apr;29(4):305-13. doi: 10.1046/j.1365-2842.2002.00824.x.
Dentine sensitivity (DS) is a common condition which affects 8-35% of the population. Both In-Office and Over-the-Counter products have been used in treatment, usually occluding open dentine tubules on the exposed root surface. Currently there appears to be no ideal material which permanently occludes dentine tubules. Bioactive and biocompatible glasses are known to induce osteogenesis in physiological systems and may offer suitable materials for surface reactivity which could theoretically occlude tubules. A new dentifrice formulation containing a modified Bioglass material replacing part of the abrasive silica component was compared with original 45S6 bioactive glass. Dentine discs were treated with original Bioglass, three coded dentifrices containing 0, 2.5 and 7.5% Bioglass and two further selected dentifrice products. These specimens were prepared for scanning electron microscopy (SEM) and viewed in a Cambridge stereoscan 90B. The results demonstrated that original bioactive glass particles covered the dentine surface and/or occluded dentine tubules, although this original formulation was easily dislodged. Dentifrice with different ratios of added Bioglass was assessed to provide greater surface coverage and tubule occlusion than without Bioglass. It was concluded that the inclusion of bioactive glass particles in a suitably formulated vehicle may be an effective agent for the treatment of dentine sensitivity.
牙本质敏感（DS）是一种常见病症，影响着8%至35%的人群。诊所使用的产品和非处方产品都已用于治疗，通常是封闭暴露根面上开放的牙本质小管。目前似乎没有能永久封闭牙本质小管的理想材料。已知具有生物活性和生物相容性的玻璃在生理系统中可诱导骨生成，并且可能提供理论上可封闭小管的具有合适表面反应性的材料。将一种含有改性生物玻璃材料替代部分磨料二氧化硅成分的新型牙膏配方与原始的45S6生物活性玻璃进行了比较。用原始生物玻璃、三种分别含有0%、2.5%和7.5%生物玻璃的编码牙膏以及另外两种选定的牙膏产品处理牙本质圆盘。这些标本被制备用于扫描电子显微镜（SEM）观察，并在剑桥立体扫描90B型显微镜下查看。结果表明，原始生物活性玻璃颗粒覆盖了牙本质表面和/或封闭了牙本质小管，尽管这种原始配方很容易脱落。添加不同比例生物玻璃的牙膏被评估为比不含生物玻璃的牙膏能提供更大的表面覆盖和小管封闭效果。得出的结论是，在适当配方的载体中加入生物活性玻璃颗粒可能是治疗牙本质敏感的有效药剂。
