Dental Physical Sciences Unit, Centre for Oral Bioengineering, Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, Floor 2 Francis Bancroft Building, Mile End Road, London E1 4NS, UK.
Molecules. 2021 Jul 17;26(14):4327. doi: 10.3390/molecules26144327.
Potassium releasing bioactive glasses (BAGs) may offer improved relief for dentine hypersensitivity compared to conventional sodium containing BAGs by releasing K ions for nerve desensitization and occluding dentinal tubules to prevent fluid flow within dentinal tubules. Potassium oxide was substituted for sodium oxide on a molar basis in a fluoride containing BAG used in toothpastes for treating dentine hypersensitivity. The BAG powders were then immersed in an artificial saliva at pH 7 and tris buffer and the pH rise and ion release behavior were characterized by ICP-OES and ISE. The potassium and sodium containing BAGs were characterized by XRD, DSC, FTIR and NMR. Both BAGs presented amorphous diffraction patterns and the glass transition temperature of the potassium glass was higher than that of the sodium glass. The P MAS-NMR spectra indicated a peak at 2.7 ppm corresponding to apatite and a small peak at -103 ppm indicated crystallization to fluorapatite. Both BAGs dissolved and formed apatite at similar rates, although the dissolution of the potassium glass was slightly slower and it released less fluoride as a result of partial nanocrystallization to fluorapatite upon quenching. The potassium release from the potassium ions could potentially result in nerve deactivation when used in toothpastes.
钾释放型生物活性玻璃（BAG）通过释放 K 离子使神经脱敏和封闭牙本质小管来阻止牙本质小管内的流体流动，与传统的含钠 BAG 相比，可能为牙本质过敏症提供更好的缓解。在用于治疗牙本质过敏症的牙膏中，含氟 BAG 中的氧化钠被氧化钾替代，摩尔比为。然后将 BAG 粉末浸入 pH 值为 7 的人工唾液和 tris 缓冲液中，并通过 ICP-OES 和 ISE 对 pH 值升高和离子释放行为进行了表征。用 XRD、DSC、FTIR 和 NMR 对含钾和钠的 BAG 进行了表征。两种 BAG 均呈现出无定形衍射图案，钾玻璃的玻璃化转变温度高于钠玻璃。MAS-NMR 谱表明在 2.7 ppm 处有一个对应于磷灰石的峰，在-103 ppm 处有一个小峰表明结晶为氟磷灰石。两种 BAG 以相似的速率溶解并形成磷灰石，尽管钾玻璃的溶解速度稍慢，由于淬火时部分纳米晶化为氟磷灰石，因此释放的氟化物较少。钾离子从钾离子中释放出来，当用于牙膏中时，可能会导致神经失活。
