Kao Chung-Lan, Chou Ching-Kuang, Tsai Der-Chong, Hsu Wen-Ming, Liu Jorn-Hon, Wang Chih-Shun, Lin Jung-Chun, Wu Chih-Chiau, Peng Chi-Hsieh, Chang Charn-Jung, Kao Chung-Luen, Chiou Shih-Hwa
Department of Physical Medicine, Taipei Veterans General Hospital, Taiwan, Republic of China.
J Cataract Refract Surg. 2002 Mar;28(3):507-12. doi: 10.1016/s0886-3350(01)01102-6.
To determine the role of nitric oxide (NO) in the clinical manifestations of cataract in different age and etiological groups.
Multicenter study, Taipei, Taiwan, Republic of China.
Aqueous humor samples were obtained from 114 cataract patients in different etiological and age groups (eg, juvenile, traumatic, and age-related cataract). Using chemiluminescence assay, NO was detected through the light generated by ozone and NO interaction. The amount of NO production was calculated and compared among groups. The results were correlated with patient age.
The NO levels in aqueous humor were highest in the 12 patients with traumatic cataract and lowest in the 15 patients with juvenile cataract (47.59 micromol/L +/- 12.81 [SD] and 7.66 +/- 2.62 micromol/L, respectively; P <.001). Aqueous humor NO levels were correlated with age and were highest in patients older than 80 years (mean 38.78 +/- 6.29 micromol/L) and in those with mature cataract (mean 40.15 +/- 6.15 micromol/L) (P <.05).
The NO levels in the aqueous humor increased with age and traumatic events. The results suggest that NO could be a risk factor in cataract formation.
确定一氧化氮（NO）在不同年龄和病因组白内障临床表现中的作用。
中国台湾台北的多中心研究。
从114例不同病因和年龄组（如青少年、外伤性和年龄相关性白内障）的白内障患者中获取房水样本。采用化学发光分析法，通过臭氧与NO相互作用产生的光来检测NO。计算并比较各组NO的产生量。结果与患者年龄相关。
12例外伤性白内障患者房水中的NO水平最高，15例青少年白内障患者房水中的NO水平最低（分别为47.59微摩尔/升±12.81[标准差]和7.66±2.62微摩尔/升；P<.001）。房水中的NO水平与年龄相关，80岁以上患者（平均38.78±6.29微摩尔/升）和成熟白内障患者（平均40.15±6.15微摩尔/升）的房水中NO水平最高（P<.05）。
房水中的NO水平随年龄和外伤事件而升高。结果表明，NO可能是白内障形成的一个危险因素。
