从扁平疣柄牛肝菌子实体中分离得到的新型羊毛甾烷型化合物——扁平酸A - H。
New lanostanoids, elfvingic acids A-H, from the fruit body of Elfvingia applanata.
作者信息
Yoshikawa Kazuko, Nishimura Naoko, Bando Shinya, Arihara Shigenobu, Matsumura Eiko, Katayama Satoshi
机构信息
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-Cho, Tokushima 770-8514, Japan.
出版信息
J Nat Prod. 2002 Apr;65(4):548-52. doi: 10.1021/np0103160.
Eight new lanostanoids, 12alpha,15beta-dihydroxy-3,7,11,23-tetraoxolanost-8,(20Z)(22)-dien-26-oic acid (1), 7beta,8beta-epoxy-15beta,20S-dihydroxy-3,12,23-trioxolanost-9(11),16-dien-26-oic acid (2), 7beta,8beta-epoxy-3beta,15beta,20S-trihydroxy-12,23-dioxolanost-9(11),16-dien-26-oic acid (3), 7beta,8beta-epoxy-2alpha,3beta,15beta,20S-tetrahydroxy-12,23-dioxolanost-9(11),16-dien-26-oic acid (4), 7beta,8beta-epoxy-3beta,15beta,20S,28-tetrahydroxy-12,23-dioxolanost-9(11),16-dien-26-oic acid (5), 7beta,8beta-epoxy-3beta,15beta,19,20S-tetrahydroxy-12,23-dioxolanost-9(11),16-dien-26-oic acid (6), 8beta,15beta,20S-trihydroxy-3,7,12,23-tetraoxolanost-9(11),16-dien-26-oic acid (7), 7alpha,8alpha-epoxy-15beta,23xi-dihydroxy-12-oxo-3,4-secolanost-4(28),9(11),(20Z)(22)-trien-3,26-dioic acid (8), and the methyl ester of 8 (8a) were isolated from the fruit bodies of Elfvingia applanata. Their structures were established primarily by NMR experiments, and their biological activity against Kato III and Ehlrich cells was investigated.
从平盖丝膜菌（Elfvingia applanata）子实体中分离得到8个新羊毛甾烷型化合物，分别为12α,15β - 二羟基 - 3,7,11,23 - 四氧代羊毛甾 - 8,(20Z)(22) - 二烯 - 26 - 酸（1）、7β,8β - 环氧 - 15β,20S - 二羟基 - 3,12,23 - 三氧代羊毛甾 - 9(11),16 - 二烯 - 26 - 酸（2）、7β,8β - 环氧 - 3β,15β,20S - 三羟基 - 12,23 - 二氧代羊毛甾 - 9(11),16 - 二烯 - 26 - 酸（3）、7β,8β - 环氧 - 2α,3β,15β,20S - 四羟基 - 12,23 - 二氧代羊毛甾 - 9(11),16 - 二烯 - 26 - 酸（4）、7β,8β - 环氧 - 3β,15β,20S,28 - 四羟基 - 12,23 - 二氧代羊毛甾 - 9(11),16 - 二烯 - 26 - 酸（5）、7β,8β - 环氧 - 3β,15β,19,20S - 四羟基 - 12,23 - 二氧代羊毛甾 - 9(11),16 - 二烯 - 26 - 酸（6）、8β,15β,20S - 三羟基 - 3,7,12,23 - 四氧代羊毛甾 - 9(11),16 - 二烯 - 26 - 酸（7）、7α,8α - 环氧 - 15β,23ξ - 二羟基 - 12 - 氧代 - 3,4 - 裂环羊毛甾 - 4(28),9(11),(20Z)(22) - 三烯 - 3,26 - 二酸（8）以及8的甲酯（8a）。其结构主要通过核磁共振实验确定，并研究了它们对Kato III细胞和艾氏腹水癌细胞的生物活性。
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