Anderson K E, Stevens C E, Tsuei J J, Lee W C, Sun S C, Beasley P
Am J Dis Child. 1975 Dec;129(12):1389-92. doi: 10.1001/archpedi.1975.02120490007003.
Hepatitis B antigen (HB Ag) was detected by complement fixation (CF) in serum samples of 7.5% of 1,106 pregnant Chinese women tested in Taipei, Taiwan. HG Ag persisted in all but one of 42 women followed for 1 to 18 months (average, nine months) after delivery, and 27 of the 43 infants (63%) born to those women became antigen-positive. Persistance of the antigen was more common than transient or intermittent antigenemia. Twelve had antigenemia when first tested, while 15 later developed antigenemia, usually during the first six months of life. Only one infant developed antibody to HG Ag (anti-HB Ag), and this occurred after transient antigenemia. The HB Ag was found in two of 32 (6%) fathers, and in 18 of 27 (67%) older siblings. The antigen was more common among siblings of antigen-positive than among those of antigen-negative infants. These findings demonstrate that in Taiwan, infants born to mothers who are asymptomatic carriers of HB Ag commonly become infected by heaptitis B (HB) virus. Exposure of infants near the time of birth may be important maintaining the high, chronic HB Ag carrier rate in Taiwan.
在台湾台北对1106名中国孕妇进行检测，通过补体结合试验（CF）在7.5%的孕妇血清样本中检测到乙肝抗原（HB Ag）。在产后随访1至18个月（平均9个月）的42名女性中，除1人外其余所有人的HB Ag都持续存在，这些女性所生的43名婴儿中有27名（63%）抗原呈阳性。抗原持续存在比短暂性或间歇性抗原血症更为常见。12人首次检测时就有抗原血症，而另外15人后来出现抗原血症，通常是在生命的头六个月内。只有1名婴儿产生了针对HB Ag的抗体（抗-HB Ag），且这发生在短暂性抗原血症之后。在32名父亲中有2名（6%）检测到HB Ag，在27名年长同胞中有18名（67%）检测到。抗原在抗原阳性婴儿的同胞中比在抗原阴性婴儿的同胞中更为常见。这些发现表明，在台湾，母亲为无症状HB Ag携带者所生的婴儿通常会感染乙肝（HB）病毒。出生时附近婴儿的接触可能对台湾高慢性HB Ag携带率的维持很重要。
