Gerety R J, Schweitzer I L
J Pediatr. 1977 Mar;90(3):368-74. doi: 10.1016/s0022-3476(77)80695-1.
Eighteen women who developed type B hepatitis late in pregnancy or early in the postpartum period (Groups I and II), 12 women who were chronically infected with the hepatitis B virus (Groups III and IV), and 32 of their offspring were tested for hepatits B surface antigen, antibody to the hepatitis B surface antigen, antibody to the hepatitis B core antigen, and the recently discovered hepatitis B-associated e antigen and its antibody. Twelve of 18 infants born to Group I and Group II mothers and 5 of 14 infants born to Group III and Group IV mothers became chronically infected with HBV: the outcome did not appear to be influenced by maternal anti-HBc titers, by HBsAg subtype, by the presence or absence of HBsAg in the cord sera, or by the infants' birth weights or gestational ages. The presence of maternal e Ag, however, did correlate with the development of chronic HBV infections in the infants studied. The e Ag appeared in five infants born of e Ag-negative mothers but did not appear to be associated with the morbid prognosis which generally accompanies its presence in adult HBsAg carriers. Data also suggest that maternal anti-e may favor HBsAg clearance and recovery in neonatally acquired HBV infections.
18名在妊娠晚期或产后早期患乙型肝炎的妇女（第一组和第二组）、12名慢性感染乙型肝炎病毒的妇女（第三组和第四组）及其32名后代接受了乙型肝炎表面抗原、乙型肝炎表面抗原抗体、乙型肝炎核心抗原抗体以及最近发现的乙型肝炎相关e抗原及其抗体检测。第一组和第二组母亲所生的18名婴儿中有12名，第三组和第四组母亲所生的14名婴儿中有5名慢性感染了乙肝病毒：这一结果似乎不受母亲抗-HBc滴度、HBsAg亚型、脐血血清中有无HBsAg或婴儿出生体重及胎龄的影响。然而，母亲e抗原的存在与所研究婴儿慢性乙肝病毒感染的发生相关。e抗原出现在5名母亲e抗原阴性的婴儿中，但似乎与通常在成年HBsAg携带者中出现时伴随的不良预后无关。数据还表明，母亲抗-e可能有利于新生儿获得性乙肝病毒感染中HBsAg的清除和恢复。
