Terpstra A H M, Lapré J A, de Vries H T, Beynen A C
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80 166, Utrecht, The Netherlands.
Nahrung. 2002 Apr;46(2):83-6. doi: 10.1002/1521-3803(20020301)46:2<83::AID-FOOD83>3.0.CO;2-L.
We fed cholesterol-enriched (0.1% w/w) semipurified diets containing 3% of lemon pectin or 3% of the polygalacturonic acid regions fraction (smooth regions fraction) of the lemon pectin to hybrid F1B hamsters for a period of 8 weeks. A control group was fed cellulose and a positive control group was fed psyllium. The feeding of the semipurified diets resulted in an increase of plasma cholesterol levels in all the dietary groups when compared with initial values. The hamsters fed the psyllium, pectin, or the polygalacturonic acid regions fraction had significantly (P < 0.05) lower plasma cholesterol levels than the cellulose fed group throughout the experimental period. Plasma cholesterol levels in the hamsters fed the psyllium, pectin, or polygalacturonic acid regions fraction were not significantly different. Liver cholesterol concentrations were also lower in the hamsters fed the psyllium, pectin, or the polygalacturonic acid regions fraction than in the hamsters fed the cellulose, but this effect reached statistical significance only in the hamsters fed the polygalacturonic acid regions fraction. The results of these studies suggest that the polygalacturonic acid regions of the pectin molecule is responsible for the cholesterol-lowering properties of the pectin.
我们用富含胆固醇（0.1% w/w）的半纯化日粮喂养杂种F1B仓鼠8周，这些日粮分别含有3%的柠檬果胶或3%的柠檬果胶聚半乳糖醛酸区域部分（平滑区域部分）。一个对照组喂纤维素，一个阳性对照组喂车前子壳。与初始值相比，所有日粮组喂食半纯化日粮后血浆胆固醇水平均升高。在整个实验期间，喂食车前子壳、果胶或聚半乳糖醛酸区域部分的仓鼠血浆胆固醇水平显著（P < 0.05）低于喂食纤维素的组。喂食车前子壳、果胶或聚半乳糖醛酸区域部分的仓鼠血浆胆固醇水平无显著差异。喂食车前子壳、果胶或聚半乳糖醛酸区域部分的仓鼠肝脏胆固醇浓度也低于喂食纤维素的仓鼠，但这种效应仅在喂食聚半乳糖醛酸区域部分的仓鼠中达到统计学显著水平。这些研究结果表明，果胶分子的聚半乳糖醛酸区域负责果胶的降胆固醇特性。
