Thony C, Thony J, Lafontaine M, Limasset J C
IARC Sci Publ (1971). 1976(13):165-70.
A real epidemy of cutaneous cancer has appeared from 1954 in a french area specialized in the metal machining industry (valley of the Arve, Haute-Saoie). Two investigations have been carried out: - one, of clinical and epidemiological nature over a period of 15 years, has recorded 133 casesof spinocellular epitheliams often located in the scrotum and has allowed to estimate the hazard for the population of this region at 25 per 100 000 (that is to say 36 times more than for the general population). - the other, of chemical nature, has revealed on one hand that the new cutting oils, such as delivered to the utilizers, rather frequently contain benzo [a] pyrene (concentration : 0,5 to 150 ug/l), and on the other hand that the used oils are inclined to grow richer in carcinogenic hydrocarbons. The prevention must be directed towards a supplementary effort in the refining of industrial oils and proposals for toxicological threshold value, which would allow to supply machine shops with oils no longer presenting a carcinogenic hazards.
自1954年起，在法国一个专门从事金属加工行业的地区（上萨瓦省阿尔韦河谷）出现了一场真正的皮肤癌流行疫情。已经开展了两项调查：一项是为期15年的临床和流行病学调查，记录了133例常发生于阴囊的棘细胞上皮瘤病例，并据此估计该地区人群的患病风险为每10万人中有25例（也就是说，是普通人群的36倍）。另一项是化学性质的调查，一方面发现供应给使用者的新型切削油常常含有苯并[a]芘（浓度为0.5至150微克/升），另一方面发现废油中致癌碳氢化合物的含量有增加的趋势。预防措施必须致力于在工业用油精炼方面加大力度，并提出毒理学阈值建议，以便为机械加工车间提供不再具有致癌风险的油品。
