Moroz P, Jones S K, Gray B N
Centre for Applied Cancer Studies, The University of Western Australia, Nedlands, 6000, Perth, Western Australia, Australia.
Int J Hyperthermia. 2002 Jul-Aug;18(4):267-84. doi: 10.1080/02656730110108785.
The use of hyperthermia in the treatment of cancers is appealing because, as a physical therapy, hyperthermia would have far fewer restrictive side effects than chemotherapy and radiotherapy, and it could be used in combination with these therapies. However, the currently available modalities of hyperthermia are often limited by their inability to selectively target tumour tissue and, hence, they carry a high risk of collateral organ damage or they deposit heat in a very localized manner which can result in under-treatment of a tumour. Magnetically mediated hyperthermia (MMH) has the potential to address these shortcomings. MMH consists of the localization of magnetic particles or seeds within tumour tissue followed by exposure to an externally applied alternating magnetic field to cause them to heat. Since this concept was introduced (over 40 years ago), MMH has evolved into four general sub-classes: arterial embolization hyperthermia (AEH), direct injection hyperthermia (DIH), intracellular hyperthermia (IH) and interstitial implant hyperthermia (IIH). It is the purpose of this article to review these four sub-classes in terms of experimental or clinical results, advantages, limitations and current status.
热疗在癌症治疗中的应用颇具吸引力，因为作为一种物理疗法，热疗相比化疗和放疗具有更少的限制性副作用，并且可以与这些疗法联合使用。然而，目前可用的热疗方式常常受到其无法选择性靶向肿瘤组织的限制，因此，它们存在较高的附带器官损伤风险，或者以非常局部的方式沉积热量，这可能导致肿瘤治疗不足。磁介导热疗（MMH）有潜力解决这些缺点。MMH包括将磁性颗粒或种子定位在肿瘤组织内，然后暴露于外部施加的交变磁场中使其发热。自从这个概念被提出（40多年前）以来，MMH已经发展成为四个一般子类：动脉栓塞热疗（AEH）、直接注射热疗（DIH）、细胞内热疗（IH）和间质植入热疗（IIH）。本文旨在根据实验或临床结果、优点、局限性和现状对这四个子类进行综述。
