Sims Erika J, Wilson Andrew M, White Paul S, Gardiner Quentin, Lipworth Brian J
Asthma & Allergy Research Group, Department of Clinical Pharmacology & Therapeutics, University of Dundee, Dundee, Scotland, UK.
Rhinology. 2002 Jun;40(2):66-8.
The purpose of this study was to determine the variability of laboratory nasal function tests in 26 patients (18 female) with seasonal allergic rhinitis (SAR) (mean age 38.1 years). Their usual medication for SAR was withheld for 2 separate one week washout periods, separated by at least 2 weeks, in order to produce clinically significant nasal airflow obstruction. Measurements were made on both occasions for nasal nitric oxide (NO), nasal peak inspiratory flow (nPIF), oral PIF (oPIF), nasal forced inspiratory flow rate in 1 second (nFIV1), oral FIV1 (oFIV1). The respective nasal-oral ratios for FIV1 and PIF were also determined. The intra-individual coefficient of variation was: NO = 14%, nFIV1 = 4%, nFIV1/oFIV1 ratio = 10%, nPIF = 8% and nPIF/oPIF ratio = 12%. Linear regression analysis showed significant (p < 0.05) correlations between nPIF and nFIV1 (R2 = 0.45) and between nPIF/oPIF and nFIV1/oFIV1 (R2 = 0.20). In conclusion, there was a good correlation between the two methods of nasal inspiratory flow, although FIV1 had a lesser degree of variability.
本研究的目的是确定26例季节性变应性鼻炎（SAR）患者（18例女性）实验室鼻功能测试的变异性（平均年龄38.1岁）。为了产生具有临床意义的鼻气流阻塞，在至少间隔2周的2个单独的1周洗脱期内停用他们常用的SAR药物。在两个时间段均对鼻一氧化氮（NO）、鼻吸气峰流量（nPIF）、口腔吸气峰流量（oPIF）、1秒内鼻用力吸气流速（nFIV1）、口腔FIV1（oFIV1）进行测量。还确定了FIV1和PIF各自的鼻-口比率。个体内变异系数为：NO = 14%，nFIV1 = 4%，nFIV1/oFIV1比率 = 10%，nPIF = 8%，nPIF/oPIF比率 = 12%。线性回归分析显示nPIF与nFIV1之间（R2 = 0.45）以及nPIF/oPIF与nFIV1/oFIV1之间（R2 = 0.20）存在显著（p < 0.05）相关性。总之，两种鼻吸气流量方法之间存在良好的相关性，尽管FIV1的变异性程度较小。
