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尖叶唐松草新双生物碱——尖叶小檗碱诱导人高转移肺癌细胞系95-D凋亡的研究

Apoptosis of human highly metastatic lung cancer cell line 95-D induced by acutiaporberine, a novel bisalkaloid derived from Thalictrum acutifolium.

作者信息

Chen Qi, Peng Wenlie, Qi Suijian, Xu Anlong

出版信息

Planta Med. 2002 Jun;68(6):550-3. doi: 10.1055/s-2002-32546.

DOI:10.1055/s-2002-32546
PMID:12094304
Abstract

The present study demonstrates for the first time that acutiaporberine, a bisalkaloid isolated from the tranditional Chinese medical herb Thalictrum acutifolium (Hand.-Mazz.) Boivin. (TAB), induces apoptosis of a cultured highly metastatic human lung cancer cell line 95-D. Immunohistochemistry assay (IHC) and Western-blot analysis show down-regulation of bcl-2 gene and up-regulation of bax gene and c-myc gene in the treated cells. These results suggest that acutiaporberine may be a natural potential apoptosis-inducing agent for highly metastatic lung cancer.

摘要

本研究首次证明，从传统中草药尖叶唐松草（Thalictrum acutifolium (Hand.-Mazz.) Boivin.，简称TAB）中分离得到的双苄基异喹啉生物碱尖叶唐松草碱可诱导高转移性人肺癌细胞系95-D凋亡。免疫组织化学分析（IHC）和蛋白质免疫印迹分析表明，处理后的细胞中bcl-2基因下调，bax基因和c-myc基因上调。这些结果表明，尖叶唐松草碱可能是一种潜在的高转移性肺癌天然凋亡诱导剂。

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