Beltrame John F, Limaye Sananand B, Horowitz John D
Cardiology Unit, North Western Adelaide Health Service, Queen Elizabeth Hospital Campus, Adelaide University, 28 Woodville Road, Woodville South, SA 5011, Australia.
Cardiology. 2002;97(4):197-202. doi: 10.1159/000063121.
The coronary slow flow phenomenon is an angiographic finding characterized by delayed distal vessel opacification in the absence of significant epicardial coronary disease. Case-control and observational studies of patients with this phenomenon were conducted to determine the associated clinical features and prognosis. Patients with coronary slow flow (n = 47) differed from controls (n = 47), more often being current smokers (32 vs. 9%; p < 0.01) and presenting with rest pain requiring urgent admission (74 vs. 21%; p < 0.001), usually to the coronary care unit (66 vs. 17%; p < 0.01). During a median 21-month follow-up of 64 slow flow patients, 84% had recurrent chest pain. Based upon these findings and those of previous investigators, it is speculated that coronary slow flow is a new disease entity characterized by acute but recurrent perturbations of microvascular function.
冠状动脉慢血流现象是一种血管造影表现，其特征为在无明显心外膜冠状动脉疾病的情况下，远端血管显影延迟。对有此现象的患者进行了病例对照研究和观察性研究，以确定相关的临床特征和预后。冠状动脉慢血流患者（n = 47）与对照组（n = 47）不同，前者更多为现吸烟者（32% 对 9%；p < 0.01），且因静息痛需紧急入院的比例更高（74% 对 21%；p < 0.001），通常入住冠心病监护病房（66% 对 17%；p < 0.01）。在对64例慢血流患者进行的中位21个月随访中，84%的患者有复发性胸痛。基于这些发现以及既往研究者的发现，推测冠状动脉慢血流是一种以微血管功能急性但复发性紊乱为特征的新疾病实体。
