Mather L E, Lindop M J, Tucker G T, Pflug A E
Br J Anaesth. 1975 Dec;47(12):1269-75. doi: 10.1093/bja/47.12.1269.
Plasma concentrations of pethidine following i.m. gluteal injection were measured in surgical patients and volunteers. The mean plasma concentrations tended to be higher in the patients than in the volunteers; this may be a result of a slower initial absorption rate. At least 80% of the dose was absorbed from the injection site over the 6-hr period of the study. Fluctuations in plasma pethidine concentration were observed, probably caused by variations in local and systemic blood flow. This effect was more noticeable in the patient group. In general, the time-course of subjective effects in volunteers could be related to maximum plasma pethidine concentrations. However, patients appeared to be less sensitive to these effects at similar plasma drug concentrations, possibly because of catecholamine-mediated stimulus, suggesting that plasma concentrations may be a poor guide to the clinical response in patient-volunteer comparison.
在外科手术患者和志愿者中测量了臀大肌肌内注射哌替啶后的血浆浓度。患者的平均血浆浓度往往高于志愿者；这可能是初始吸收速率较慢的结果。在研究的6小时期间，至少80%的剂量从注射部位吸收。观察到血浆哌替啶浓度有波动，可能是由局部和全身血流变化引起的。这种效应在患者组中更明显。一般来说，志愿者主观效应的时间进程可能与血浆哌替啶最大浓度有关。然而，在相似的血浆药物浓度下，患者似乎对这些效应不太敏感，这可能是由于儿茶酚胺介导的刺激，这表明在患者与志愿者的比较中，血浆浓度可能不是临床反应的良好指标。
