Jacobsen J, Flachs H, Dich-Nielsen J O, Rosen J, Larsen A B, Hvidberg E F
Department of Anaesthesia, University of Copenhagen, Rigshospitalet, Denmark.
Br J Anaesth. 1988 May;60(6):623-6. doi: 10.1093/bja/60.6.623.
Plasma concentration-time curves of pethidine and norpethidine were studied in 25 children allocated after operation to three groups to receive pethidine 1 mg kg-1 i.v., i.m. or rectally. Peak concentrations occurred after 5 +/- 1, 10 +/- 2, and 60 +/- 10 min, respectively, while the maximum concentrations amounted to 2800 +/- 462, 1609 +/- 367 and 531 +/- 179 nmol litre-1, respectively. The area under the curve (0-240 min) was similarly reduced in the group with rectal administration (P less than 0.05). Compared with the i.v. data, approximately 40% systemic availability occurred after rectal application, although considerable individual variation was noted. In one child very high plasma concentrations were observed after rectal administration, possibly as a result of redistribution/recirculation phenomena. The average results are similar to those obtained when other opioids are given rectally.
对25名术后儿童进行分组研究，分别静脉注射、肌肉注射或直肠给药哌替啶1mg/kg，观察哌替啶和去甲哌替啶的血浆浓度-时间曲线。峰值浓度分别在5±1、10±2和60±10分钟后出现，而最大浓度分别为2800±462、1609±367和531±179nmol/L。直肠给药组曲线下面积（0 - 240分钟）同样降低（P<0.05）。与静脉注射数据相比，直肠给药后全身利用率约为40%，尽管存在相当大的个体差异。在一名儿童中，直肠给药后观察到非常高的血浆浓度，可能是由于再分布/再循环现象所致。平均结果与直肠给予其他阿片类药物时获得的结果相似。
