Nauck Markus, Winkelmann Bernhard R, Hoffmann Michael M, Böhm Bernhard O, Wieland Heinrich, März Winfried
Department of Medicine, University Hospital, Hugstetter Strasse 55, 79106 Freiburg, Germany.
J Mol Med (Berl). 2002 Aug;80(8):507-13. doi: 10.1007/s00109-002-0354-2. Epub 2002 Jun 21.
IL-6 plasma levels are predictive of major cardiovascular events. Recently a G/C polymorphism at position -174 in the promoter of the IL-6 gene has been associated with differences in both the IL-6 transcription rate in vitro and IL-6 levels in vivo. We examined the association of this polymorphism with coronary artery disease (CAD) and previous myocardial infarction (MI) in 2559 patients with angiographically documented CAD with ( n=1365) and without ( n=1194) MI and in a control group of 729 individuals in whom CAD had been ruled out angiographically. Assuming dominant or recessive modes of inheritance, carriers of the G allele had odds ratios of 0.98 (95% CI 0.79 - 1.20) and 0.96 (95% CI 0.80 - 1.14), respectively, for CAD, and almost identical ones for previous MI. In subgroups stratified for low cardiovascular risk, the IL-6 promoter polymorphism was also not related to the risk of CAD or MI. In addition, the plasma concentration of IL-6 did not differ between groups with different IL-6 genotypes in 942 randomly selected individuals. We conclude that the IL-6 G(-174)C polymorphism is not associated with the risk of CAD or MI and does not contribute to cardiovascular risk stratification.
白细胞介素-6（IL-6）的血浆水平可预测重大心血管事件。最近，IL-6基因启动子-174位的G/C多态性与体外IL-6转录率及体内IL-6水平的差异相关。我们在2559例经血管造影证实患有冠心病（CAD）的患者中研究了这种多态性与冠心病及既往心肌梗死（MI）的关系，其中有MI的患者1365例，无MI的患者1194例，并与729例经血管造影排除CAD的个体组成的对照组进行比较。假设遗传方式为显性或隐性，对于CAD，G等位基因携带者的比值比分别为0.98（95%可信区间0.79 - 1.20）和0.96（95%可信区间0.80 - 1.14），对于既往MI，比值比几乎相同。在按低心血管风险分层的亚组中，IL-6启动子多态性也与CAD或MI的风险无关。此外，在942例随机选择的个体中，不同IL-6基因型组之间的IL-6血浆浓度无差异。我们得出结论，IL-6 G（-174）C多态性与CAD或MI的风险无关，对心血管风险分层无贡献。
