Ernst E
Department of Complementary Medicine, School of Sport and Health Sciences, University of Exeter, Exeter, UK.
J Intern Med. 2002 Aug;252(2):107-13. doi: 10.1046/j.1365-2796.2002.00999.x.
The popularity of Chinese herbal medicines (CHMs) demands a critical analysis of safety issues. The aim of this systematic review is to summarize data regarding adulterations of CHMs with conventional drugs. Literature searches were carried out in six databases. Articles containing original data on adulterations were considered without language restrictions. Eighteen case reports, two case series and four analytical investigations were identified. The list of adulterants contains drugs associated with serious adverse effects like corticosteroids. In several instances, patients were seriously harmed. One report from Taiwan suggests that 24% of all samples were contaminated with at least one conventional pharmacological compound. It is concluded that adulteration of CHMs with synthetic drugs is a potentially serious problem which needs to be addressed by adequate regulatory measures.
中草药（CHMs）的广泛使用要求对其安全性问题进行批判性分析。本系统评价的目的是总结有关中草药被传统药物掺假的数据。在六个数据库中进行了文献检索。纳入了包含掺假原始数据的文章，无语言限制。共识别出18篇病例报告、2个病例系列和4项分析性研究。掺假物清单中包括与严重不良反应相关的药物，如皮质类固醇。在一些案例中，患者受到了严重伤害。台湾的一份报告表明，所有样本中有24%至少被一种传统药理化合物污染。结论是，中草药被合成药物掺假是一个潜在的严重问题，需要通过适当的监管措施加以解决。
