Schettgen Thomas, Heudorf Ursel, Drexler Hans, Angerer Jürgen
Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-University of Erlangen-Nürnberg, Schillerstrasse 25/29, D-91054, Erlangen, Germany.
Toxicol Lett. 2002 Aug 5;134(1-3):141-5. doi: 10.1016/s0378-4274(02)00183-2.
Inhabitants (1177) of a residential area in Frankfurt/Main have been investigated with respect to internal exposure to pyrethroids. Biological monitoring revealed a body burden of pyrethroids. The 95th per thousand for the urinary metabolites of pyrethroids, such as permethrin and cypermethrin, cis and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (cis-DCCA and trans-DCCA), was determined to be 0.5 and 1.4 microg/l, respectively. 95th per thousand for cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (DBCA), a specific metabolite of deltamethrin, and 4-fluoro-3-phenoxybenzoic acid (F-PBA), a metabolite of cyfluthrin, were 0.3 and 0.27 microg/l, respectively. The metabolic pattern found for these samples points out that pyrethroids are probably ingested orally with daily diet.
对美因河畔法兰克福一个居民区的1177名居民进行了拟除虫菊酯体内暴露情况的调查。生物监测显示居民体内存在拟除虫菊酯负荷。拟除虫菊酯(如氯菊酯和氯氰菊酯)的尿代谢产物顺式和反式-3-(2,2-二氯乙烯基)-2,2-二甲基环丙烷-1-羧酸(顺式-DCCA和反式-DCCA)的第95百分位数分别测定为0.5和1.4微克/升。溴氰菊酯的特定代谢产物顺式-3-(2,2-二溴乙烯基)-2,2-二甲基环丙烷-1-羧酸(DBCA)和氟氯氰菊酯的代谢产物4-氟-3-苯氧基苯甲酸(F-PBA)的第95百分位数分别为0.3和0.27微克/升。这些样本的代谢模式表明,拟除虫菊酯可能通过日常饮食经口摄入。