来自帝王贝母的新型甾体生物碱及其胆碱酯酶抑制活性。

New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities.

作者信息

Akhtar Muhammad Nadeem, Choudhary Muhammad Iqbal, Tsuda Yoshisuke, Sener Bilge, Khalid Assad, Parvez Masood

机构信息

H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan.

出版信息

Chem Pharm Bull (Tokyo). 2002 Aug;50(8):1013-6. doi: 10.1248/cpb.50.1013.

DOI:10.1248/cpb.50.1013

PMID:12192128

Abstract

Two new cevanine steroidal alkaloids, impericine (1) and forticine (2) along with known bases delavine (3), persicanidine A (4), and imperialine (5) were isolated from the bulbs of Fritillaria imperialis. The structures of impericine (1) [(20R,22S,25S)-5alpha-cevanin-23-ene-3beta,6beta,16beta-triol] and forticine (2) [(20S,22S,25S)-5alpha-cevanine-3beta,6beta-diol] were determined with the help of spectroscopic studies. These steroidal bases showed anti-acetylcholinesterase and anti-butyrylcholinesterase inhibitory activity.

摘要

从帝王贝母的鳞茎中分离出两种新的瑟文宁甾体生物碱，帝王贝母碱（1）和强壮贝母碱（2），以及已知的生物碱德拉文碱（3）、波斯紫堇定A（4）和帝王贝母碱（5）。借助光谱研究确定了帝王贝母碱（1）[（20R，22S，25S）-5α-瑟文宁-23-烯-3β，6β，16β-三醇]和强壮贝母碱（2）[（20S，22S，25S）-5α-瑟文宁-3β，6β-二醇]的结构。这些甾体碱表现出抗乙酰胆碱酯酶和抗丁酰胆碱酯酶抑制活性。