Sartori Ana Marli C, Neto José Eluf, Nunes Elizabete Visone, Braz Lucia Maria Almeida, Caiaffa-Filho Hélio H, Oliveira Oswaldo da Cruz, Neto Vicente Amato, Shikanai-Yasuda Maria Aparecida
Clinic of Infectious and Parasitic Disease and AIDS Clinic, University of São Paulo School of Medicine, São Paulo, Brazil.
J Infect Dis. 2002 Sep 15;186(6):872-5. doi: 10.1086/342510. Epub 2002 Aug 9.
This study evaluated Trypanosoma cruzi parasitemia in persons with chronic Chagas disease, compared the parasitemia in human immunodeficiency virus (HIV)-positive and -negative subjects, and, for HIV-positive subjects, analyzed the association between parasitemia and occurrence of acquired immunodeficiency syndrome-defining illnesses, CD4 cell counts, HIV loads, and antiretroviral therapy. In total, 110 adults with chronic Chagas disease (29 HIV positive, 81 HIV negative) were studied. T. cruzi parasitemia was evaluated by xenodiagnosis, blood culture, and direct microscopic examination of blood. T. cruzi parasitemia was detected significantly more frequently in HIV-positive than in HIV-negative subjects (odds ratio, 12.3; 95% confidence interval, 3.7-41.2). HIV-positive patients also had higher levels of parasitemia. No statistically significant association was seen between parasitemia and the variables of interest among the HIV-positive subjects.
本研究评估了慢性恰加斯病患者的克氏锥虫血症，比较了人类免疫缺陷病毒（HIV）阳性和阴性受试者的锥虫血症情况，并且对于HIV阳性受试者，分析了锥虫血症与获得性免疫缺陷综合征定义疾病的发生、CD4细胞计数、HIV载量及抗逆转录病毒治疗之间的关联。总共研究了110例慢性恰加斯病成人患者（29例HIV阳性，81例HIV阴性）。通过异种接种诊断、血培养及血液直接显微镜检查评估克氏锥虫血症。在HIV阳性受试者中检测到克氏锥虫血症的频率显著高于HIV阴性受试者（优势比，12.3；95%置信区间，3.7 - 41.2）。HIV阳性患者的锥虫血症水平也更高。在HIV阳性受试者中，未观察到锥虫血症与相关变量之间存在统计学显著关联。
