Deasy Bridget M, Li Yong, Huard Johnny
Bioengineering Department, University of Pittsburgh School of Medicine, PA 15260, USA.
Curr Opin Biotechnol. 2004 Oct;15(5):419-23. doi: 10.1016/j.copbio.2004.08.004.
Tissue engineering and cell therapy approaches aim to take advantage of the repopulating ability and plasticity of multipotent stem cells to regenerate lost or diseased tissue. Researchers continue to investigate stem cells in mature tissues and demonstrate the potential ability of organ-specific cells to differentiate into multiple lineages. One stem cell that displays such promise is the muscle-derived stem cell (MDSC). Data supporting the existence of MDSCs have emerged as part of investigations to improve myoblast cell transplantation for the treatment of muscular dystrophies. As these efforts continue, the potential for MDSC-based therapy for other musculoskeletal injuries, as well as for cardiac and smooth muscle injuries, is currently being explored.
组织工程和细胞治疗方法旨在利用多能干细胞的再生能力和可塑性来再生受损或患病组织。研究人员继续在成熟组织中研究干细胞，并证明器官特异性细胞分化为多种谱系的潜在能力。一种展现出这种前景的干细胞是肌肉衍生干细胞（MDSC）。作为改善成肌细胞移植治疗肌肉萎缩症研究的一部分，支持MDSC存在的数据已经出现。随着这些研究的继续，目前正在探索基于MDSC的疗法治疗其他肌肉骨骼损伤以及心脏和平滑肌损伤的潜力。
