Abdel-Khalik S M, Miyase T, Melek F R, el-Shabraway O A, Mahmoud I I, Mina S A
Pharmacognosy Department, Faculty of Pharmacy, Helwan University, Egypt.
Pharmazie. 2002 Aug;57(8):562-6.
The structures of one new monodesmosidic spirostanoside and one new bisdesmosidic furanostanol glycoside isolated from leaves of Agave lophantha Schiede have been determined by means of spectroscopic and chemical methods as (25R)-5 beta-spirostan-3 beta-ol-3-O-(beta-D-apiofuranosyl(1-->4)beta-D -glucopyranosyl(1-->3)[beta-D-glucopyranosyl(1-->2)]beta-D -galactopyranoside) and 26-O-beta-D-glucopyranosyl(25R)-5 beta-furost-20(22)-ene-3 beta, 26-diol-3-O-(beta-D-xylopyranosyl(1-->3)-[beta-D-glucopyranosyl(1--2)] beta-D-galactopyranoside), respectively. The 1H and 13C NMR resonances of the two compounds were assigned by NMR (1H, 13C, HOHAHA, 1H-1H COSY, HMQC, HMBC, NOE difference) studies. The pharmacological activities of the saponin containing fraction are discussed.
从龙舌兰属植物洛氏龙舌兰（Agave lophantha Schiede）叶片中分离得到的一个新的单糖苷甾体螺甾烷醇苷和一个新的双糖苷呋喃甾烷醇苷的结构，已通过光谱和化学方法确定，分别为(25R)-5β-螺甾烷-3β-醇-3-O-(β-D-阿吡喃糖基(1→4)β-D-吡喃葡萄糖基(1→3)[β-D-吡喃葡萄糖基(1→2)]β-D-吡喃半乳糖苷)和26-O-β-D-吡喃葡萄糖基(25R)-5β-呋喃甾-20(22)-烯-3β,26-二醇-3-O-(β-D-吡喃木糖基(1→3)-[β-D-吡喃葡萄糖基(1→2)]β-D-吡喃半乳糖苷)。通过核磁共振（1H、13C、HOHAHA、1H-1H COSY、HMQC、HMBC、NOE差值）研究确定了这两种化合物的1H和13C NMR共振信号。讨论了含皂苷部分的药理活性。
