Landers Rüdiger, Hübner Ute, Schmelzeisen Rainer, Mülhaupt Rolf
Freiburger Materialforschungszentrum and Institut für Makromolekulare Chemie der Albert-Ludwigs-Universität Freiburg, Germany.
Biomaterials. 2002 Dec;23(23):4437-47. doi: 10.1016/s0142-9612(02)00139-4.
In the year 2000 a new rapid prototyping (RP) technology was developed at the Freiburg Materials Research Center to meet the demands for desktop fabrication of scaffolds useful in tissue engineering. A key feature of this RP technology is the three-dimensional (3D) dispensing of liquids and pastes in liquid media. In contrast to conventional RP systems, mainly focused on melt processing, the 3D dispensing RP process (3D plotting) can apply a much larger variety of synthetic as well as natural materials, including aqueous solutions and pastes, to fabricate scaffolds for application in tissue engineering. For the first time, hydrogel scaffolds with a designed external shape and a well-defined internal pore structure were prepared by this RP process. Surface coating and pore formation were achieved to facilitate cell adhesion and cell growth. The versatile application potential of new hydrogel scaffolds was demonstrated in cell culture.
2000年，弗赖堡材料研究中心开发了一种新的快速成型（RP）技术，以满足组织工程中用于桌面制造支架的需求。这种RP技术的一个关键特性是在液体介质中对液体和糊剂进行三维（3D）分配。与主要专注于熔融加工的传统RP系统不同，3D分配RP工艺（3D绘图）可以应用种类更多的合成材料和天然材料，包括水溶液和糊剂，来制造用于组织工程的支架。首次通过这种RP工艺制备了具有设计好的外形和明确内部孔隙结构的水凝胶支架。实现了表面涂层和孔隙形成，以促进细胞黏附和细胞生长。新型水凝胶支架的广泛应用潜力在细胞培养中得到了证明。
