• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Imipenem-EDTA disk method for differentiation of metallo-beta-lactamase-producing clinical isolates of Pseudomonas spp. and Acinetobacter spp.亚胺培南-乙二胺四乙酸纸片法用于区分产金属β-内酰胺酶的铜绿假单胞菌和不动杆菌临床分离株
J Clin Microbiol. 2002 Oct;40(10):3798-801. doi: 10.1128/JCM.40.10.3798-3801.2002.
2
Evaluation of the Hodge test and the imipenem-EDTA double-disk synergy test for differentiating metallo-beta-lactamase-producing isolates of Pseudomonas spp. and Acinetobacter spp.评估 Hodge 试验和亚胺培南 - EDTA 双纸片协同试验用于鉴别产金属β-内酰胺酶的假单胞菌属和不动杆菌属菌株
J Clin Microbiol. 2003 Oct;41(10):4623-9. doi: 10.1128/JCM.41.10.4623-4629.2003.
3
Prevalence of metallo-beta lactamase (MBL) producing Pseudomonas spp. and Acinetobacter spp. in a tertiary care hospital in India.印度一家三级护理医院中产金属β-内酰胺酶（MBL）的假单胞菌属和不动杆菌属的流行情况。
J Infect. 2006 May;52(5):311-4. doi: 10.1016/j.jinf.2005.08.013. Epub 2005 Oct 6.
4
Evaluation of double-disk potentiation and disk potentiation tests using dipicolinic acid for detection of metallo-β-lactamase-producing pseudomonas spp. and Acinetobacter spp.采用二吡啶酸评估双碟增效试验和碟增效试验检测产金属β-内酰胺酶的铜绿假单胞菌和不动杆菌属。
J Clin Microbiol. 2012 Oct;50(10):3227-32. doi: 10.1128/JCM.00818-12. Epub 2012 Jul 25.
5
Combined use of the modified Hodge test and carbapenemase inhibition test for detection of carbapenemase-producing Enterobacteriaceae and metallo-β-lactamase-producing Pseudomonas spp.改良 Hodge 试验与碳青霉烯酶抑制试验联合用于检测产碳青霉烯酶肠杆菌科细菌和产金属β-内酰胺酶铜绿假单胞菌属细菌
Ann Lab Med. 2015 Mar;35(2):212-9. doi: 10.3343/alm.2015.35.2.212. Epub 2015 Feb 12.
6
Metallo-beta-lactamase-producing Gram-negative bacilli in Korean Nationwide Surveillance of Antimicrobial Resistance group hospitals in 2003: continued prevalence of VIM-producing Pseudomonas spp. and increase of IMP-producing Acinetobacter spp.2003年韩国全国抗菌药物耐药性监测组医院中产金属β-内酰胺酶的革兰氏阴性杆菌：产VIM型假单胞菌属持续流行及产IMP型不动杆菌属增多
Diagn Microbiol Infect Dis. 2004 Sep;50(1):51-8. doi: 10.1016/j.diagmicrobio.2004.05.002.
7
EDTA susceptibility leading to false detection of metallo-beta-lactamase in Pseudomonas aeruginosa by Etest and an imipenem-EDTA disk method.通过Etest和亚胺培南-乙二胺四乙酸纸片法检测，乙二胺四乙酸敏感性导致铜绿假单胞菌中金属β-内酰胺酶的假阳性检测。
Int J Antimicrob Agents. 2005 Oct;26(4):340-1. doi: 10.1016/j.ijantimicag.2005.07.004.
8
A simple screening test for the detection of metallo-β-lactamase-producing Pseudomonas aeruginosa and Acinetobacter in a tertiary care hospital.一种用于在三级护理医院中检测产金属β-内酰胺酶的铜绿假单胞菌和不动杆菌的简单筛查试验。
Trop Biomed. 2012 Dec;29(4):588-97.
9
Dipicolinic acid-based disk methods for detection of metallo-beta-lactamase-producing Pseudomonas spp. and Acinetobacter spp.基于吡啶二羧酸的纸片法检测产金属β-内酰胺酶的假单胞菌属和不动杆菌属细菌
Diagn Microbiol Infect Dis. 2008 Sep;62(1):102-5. doi: 10.1016/j.diagmicrobio.2008.04.015. Epub 2008 Jun 11.
10
Modified Hodge and EDTA-disk synergy tests to screen metallo-beta-lactamase-producing strains of Pseudomonas and Acinetobacter species.改良 Hodge 试验和 EDTA 纸片协同试验用于筛选产金属β-内酰胺酶的铜绿假单胞菌和不动杆菌属菌株。
Clin Microbiol Infect. 2001 Feb;7(2):88-91. doi: 10.1046/j.1469-0691.2001.00204.x.

引用本文的文献

1
Reviving Furosemide as a Metallo-β-Lactamase Inhibitor against MDR .将速尿重新用作抗多重耐药性金属β-内酰胺酶抑制剂
J Microbiol Biotechnol. 2025 Aug 7;35:e2506023. doi: 10.4014/jmb.2506.06023.
2
Global Epidemiology and Antimicrobial Resistance of Metallo-β-Lactamase (MBL)-Producing Acinetobacter Clinical Isolates: A Systematic Review.产金属β-内酰胺酶（MBL）的不动杆菌临床分离株的全球流行病学及抗菌药物耐药性：一项系统评价
Pathogens. 2025 Jun 3;14(6):557. doi: 10.3390/pathogens14060557.
3
Phenotypic and Genotypic Characterization of Clinical Isolates of Carbapenem-Resistant Acinetobacter baumannii: A Cross-Sectional Study From a Tertiary Care Hospital in Western Uttar Pradesh, India.耐碳青霉烯鲍曼不动杆菌临床分离株的表型和基因型特征：来自印度北方邦西部一家三级护理医院的横断面研究
Cureus. 2025 May 12;17(5):e83998. doi: 10.7759/cureus.83998. eCollection 2025 May.
4
Detection of the blaNDM-1 Gene in Carbapenem-Resistant Enterobacterales Causing Urinary Tract Infections in Patients at a Rural Teaching Hospital.在一家农村教学医院的尿路感染患者中，对产碳青霉烯酶肠杆菌科细菌中blaNDM - 1基因的检测
Cureus. 2025 Apr 6;17(4):e81811. doi: 10.7759/cureus.81811. eCollection 2025 Apr.
5
Phenotypic and genotypic characterization of carbapenemase-producing clinical isolates in Thi-Qar, Iraq.伊拉克济加尔省产碳青霉烯酶临床分离株的表型和基因型特征
Iran J Microbiol. 2025 Apr;17(2):268-277. doi: 10.18502/ijm.v17i2.18387.
6
Therapeutic approaches for septicemia induced by multidrug-resistant bacteria using desert-adapted plants.利用适应沙漠环境的植物治疗多重耐药菌引起的败血症的方法。
Front Cell Infect Microbiol. 2025 Apr 22;15:1493769. doi: 10.3389/fcimb.2025.1493769. eCollection 2025.
7
Diagnostic algorithm for the detection of carbapenemases and extended-spectrum β-lactamases in carbapenem-resistant .耐碳青霉烯类细菌中碳青霉烯酶和超广谱β-内酰胺酶检测的诊断算法
Microbiol Spectr. 2025 Jun 3;13(6):e0319624. doi: 10.1128/spectrum.03196-24. Epub 2025 Apr 16.
8
Molecular characterization of metallo-beta-lactamase producers among carbapenem-resistant Pseudomonas aeruginosa from clinical samples in a tertiary care hospital, Lucknow, India.印度勒克瑙一家三级护理医院临床样本中耐碳青霉烯类铜绿假单胞菌产金属β-内酰胺酶菌株的分子特征分析
Naunyn Schmiedebergs Arch Pharmacol. 2025 Feb 18. doi: 10.1007/s00210-025-03913-6.
9
Biochemical properties and substrate specificity of GOB-38 in Elizabethkingia anophelis.嗜蚊伊氏放线菌中GOB-38的生化特性及底物特异性
Sci Rep. 2025 Jan 2;15(1):351. doi: 10.1038/s41598-024-82748-2.
10
Extended spectrum and metalo beta lactamase producing gram negative bacterial pathogens from cockroaches collected at hospital, Southern Ethiopia.从埃塞俄比亚南部医院收集的蟑螂中分离出产超广谱和金属β-内酰胺酶的革兰氏阴性细菌病原体。
Antimicrob Resist Infect Control. 2024 Aug 13;13(1):87. doi: 10.1186/s13756-024-01442-0.

本文引用的文献

1
Molecular characterization of metallo-beta-lactamase-producing Acinetobacter baumannii and Acinetobacter genomospecies 3 from Korea: identification of two new integrons carrying the bla(VIM-2) gene cassettes.韩国产金属β-内酰胺酶的鲍曼不动杆菌和不动杆菌基因组种3的分子特征：鉴定两个携带bla(VIM-2)基因盒的新整合子
J Antimicrob Chemother. 2002 May;49(5):837-40. doi: 10.1093/jac/dkf043.
2
bla(VIM-2) cassette-containing novel integrons in metallo-beta-lactamase-producing Pseudomonas aeruginosa and Pseudomonas putida isolates disseminated in a Korean hospital.在一家韩国医院传播的产金属β-内酰胺酶的铜绿假单胞菌和恶臭假单胞菌分离株中含有bla(VIM-2) 盒的新型整合子
Antimicrob Agents Chemother. 2002 Apr;46(4):1053-8. doi: 10.1128/AAC.46.4.1053-1058.2002.
3
Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new bla(IMP) allele, bla(IMP-7).携带新的bla(IMP)等位基因bla(IMP-7)的耐碳青霉烯类铜绿假单胞菌医院感染暴发。
Antimicrob Agents Chemother. 2002 Jan;46(1):255-8. doi: 10.1128/AAC.46.1.255-258.2002.
4
Outbreak of infection with multidrug-resistant Klebsiella pneumoniae carrying bla(IMP-8) in a university medical center in Taiwan.台湾一所大学医学中心发生携带bla(IMP - 8)的多重耐药肺炎克雷伯菌感染暴发。
J Clin Microbiol. 2001 Dec;39(12):4433-9. doi: 10.1128/JCM.39.12.4433-4439.2001.
5
Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.21世纪的超广谱β-内酰胺酶：这种重要耐药威胁的特征、流行病学及检测
Clin Microbiol Rev. 2001 Oct;14(4):933-51, table of contents. doi: 10.1128/CMR.14.4.933-951.2001.
6
Metallo-beta-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme.台湾临床分离的假单胞菌中的金属β-内酰胺酶以及VIM-2酶新变体VIM-3的鉴定
Antimicrob Agents Chemother. 2001 Aug;45(8):2224-8. doi: 10.1128/AAC.45.8.2224-2228.2001.
7
Modified Hodge and EDTA-disk synergy tests to screen metallo-beta-lactamase-producing strains of Pseudomonas and Acinetobacter species.改良 Hodge 试验和 EDTA 纸片协同试验用于筛选产金属β-内酰胺酶的铜绿假单胞菌和不动杆菌属菌株。
Clin Microbiol Infect. 2001 Feb;7(2):88-91. doi: 10.1046/j.1469-0691.2001.00204.x.
8
Carbapenem-hydrolysing VIM-2 metallo- beta-lactamase in Pseudomonas aeruginosa from Greece.希腊铜绿假单胞菌中可水解碳青霉烯类的VIM-2金属β-内酰胺酶
J Antimicrob Chemother. 2000 Dec;46(6):1041-2. doi: 10.1093/jac/46.6.1041.
9
Characterization of the metallo-beta-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of bla(IMP) allelic variants carried by gene cassettes of different phylogeny.鲍曼不动杆菌AC-54/97金属β-内酰胺酶决定簇的特征分析揭示了不同系统发育的基因盒所携带的bla(IMP)等位基因变体的存在。
Antimicrob Agents Chemother. 2000 May;44(5):1229-35. doi: 10.1128/AAC.44.5.1229-1235.2000.
10
Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France.VIM-2的特性研究，VIM-2是一种可水解碳青霉烯类的金属β-内酰胺酶及其来自法国一株铜绿假单胞菌临床分离株的质粒和整合子携带基因。
Antimicrob Agents Chemother. 2000 Apr;44(4):891-7. doi: 10.1128/AAC.44.4.891-897.2000.

亚胺培南-乙二胺四乙酸纸片法用于区分产金属β-内酰胺酶的铜绿假单胞菌和不动杆菌临床分离株

Imipenem-EDTA disk method for differentiation of metallo-beta-lactamase-producing clinical isolates of Pseudomonas spp. and Acinetobacter spp.

作者信息

Yong Dongeun, Lee Kyungwon, Yum Jong Hwa, Shin Hee Bong, Rossolini Gian Maria, Chong Yunsop

机构信息

Department of Laboratory Medicine, Research Institute of Bacterial Resistance, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemoon-ku, Seoul 120-752, Korea.

出版信息

J Clin Microbiol. 2002 Oct;40(10):3798-801. doi: 10.1128/JCM.40.10.3798-3801.2002.

DOI:10.1128/JCM.40.10.3798-3801.2002
PMID:12354884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC130862/
Abstract

Rapid detection of metallo-beta-lactamase (MBL)-producing gram-negative bacilli is necessary to prevent their dissemination. The method using a disk with imipenem plus 750 micro g of EDTA differentiated all MBL-producing pseudomonads, and the sensitivity and specificity for acinetobacters were 95.7 and 91.0%, respectively. The imipenem-EDTA disks were stable for 12 and 16 weeks at 4 and -20 degrees C, respectively.

摘要

快速检测产金属β-内酰胺酶（MBL）的革兰氏阴性杆菌对于防止其传播至关重要。使用含亚胺培南加750微克乙二胺四乙酸（EDTA）的纸片法能区分所有产MBL的假单胞菌，对不动杆菌的敏感性和特异性分别为95.7%和91.0%。亚胺培南-EDTA纸片在4℃和-20℃分别可稳定保存12周和16周。