He Weidong, Cik Miroslav, Appendino Giovanni, Puyvelde Luc Van, Leysen Josée E, De Kimpe Norbert
Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, Ghent, B-9000, Belgium.
Mini Rev Med Chem. 2002 Apr;2(2):185-200. doi: 10.2174/1389557024605492.
Daphnane orthoesters are the active ingredients of plant remedies from the Western, Chinese and African traditional medicine, and have provided important tools to investigate medicinally relevant processes like tumour promotion, apoptosis, neurotrophism, and VR1 activation. The occurrence, biological activity, and molecular pharmacology of these compounds will be reviewed.
瑞香烷原酸酯是西方、中国和非洲传统医学中植物药物的活性成分,为研究肿瘤促进、细胞凋亡、神经营养和VR1激活等医学相关过程提供了重要工具。本文将对这些化合物的存在、生物活性和分子药理学进行综述。