基因组学在子宫内膜异位症研究中的新兴作用。
Emerging role of genomics in endometriosis research.
作者信息
Taylor Robert N, Lundeen Scott G, Giudice Linda C
机构信息
Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco School of Medicine, 94143-0556, USA.
出版信息
Fertil Steril. 2002 Oct;78(4):694-8. doi: 10.1016/s0015-0282(02)03325-3.
OBJECTIVE
Rapidly evolving methods in genomics and proteomics research already are changing the nature of biomedical investigation. In this report we briefly review some of the seminal technological advances that inspired the genomics revolution and describe their application in the field of endometriosis research.
DESIGN
Review of different techniques successfully applied to endometriosis research.
SETTING
Collaborative investigation in academic and pharmaceutical industry laboratories.
PATIENT(S): Biopsies were obtained from consenting ovulatory women on no medications, with or without laparoscopically proven endometriosis.
RESULT(S): Genomics techniques have confirmed gene products shown to be abnormally expressed in endometriotic tissues by prior studies. In addition, identification of novel transcripts not previously appreciated in this condition were discovered. Examples of dysregulated genes in endometriosis include glycodelin, complement, early growth response-1 and transducer of erbB-1.
CONCLUSION(S): Global gene profiling studies are poised to revolutionize the diagnosis and treatment of endometriosis and other human diseases.
目的
基因组学和蛋白质组学研究中迅速发展的方法已经在改变生物医学研究的性质。在本报告中，我们简要回顾了一些引发基因组学革命的开创性技术进展，并描述了它们在子宫内膜异位症研究领域的应用。
设计
对成功应用于子宫内膜异位症研究的不同技术进行综述。
研究地点
学术和制药行业实验室的合作研究。
患者
从同意参与的未服用药物、有或无腹腔镜证实的子宫内膜异位症的排卵女性中获取活检样本。
结果
基因组学技术证实了先前研究中显示在子宫内膜异位组织中异常表达的基因产物。此外，还发现了在此病症中以前未被认识的新转录本。子宫内膜异位症中失调基因的例子包括糖蛋白、补体、早期生长反应-1和erbB-1转导子。
结论
全基因表达谱研究有望彻底改变子宫内膜异位症和其他人类疾病的诊断和治疗。
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