Leid Jeff G, Shirtliff Mark E, Costerton J W, Stoodley Paul
Department of Cell Biology and Neuroscience, Center for Biofilm Engineering, Montana State University, Bozeman, Montana 59717, USA.
Infect Immun. 2002 Nov;70(11):6339-45. doi: 10.1128/IAI.70.11.6339-6345.2002.
Staphylococcus aureus is a common pathogen responsible for nosocomial and community infections. It readily colonizes indwelling catheters, forming microbiotic communities termed biofilms. S. aureus bacteria in biofilms are protected from killing by antibiotics and the body's immune system. For years, one mechanism behind biofilm resistance to attack from the immune system's sentinel leukocytes has been conceptualized as a deficiency in the ability of the leukocytes to penetrate the biofilm. We demonstrate here that under conditions mimicking physiological shear, leukocytes attach, penetrate, and produce cytokines in response to maturing and fully matured S. aureus biofilm.
金黄色葡萄球菌是引起医院感染和社区感染的常见病原体。它很容易在留置导管上定殖，形成称为生物膜的微生物群落。生物膜中的金黄色葡萄球菌受到抗生素和人体免疫系统的保护而不被杀死。多年来，生物膜抵抗免疫系统哨兵白细胞攻击的一种机制一直被认为是白细胞穿透生物膜的能力不足。我们在此证明，在模拟生理剪切力的条件下，白细胞会附着、穿透成熟和完全成熟的金黄色葡萄球菌生物膜并产生细胞因子。
