粗糙脉孢菌中磷酸盐代谢酶的遗传控制：调控突变之间的关系。
Genetic control of phosphate-metabolizing enzymes in Neurospora crassa: relationships among regulatory mutations.
作者信息
Littlewood B S, Chia W, Metzenberg R L
出版信息
Genetics. 1975 Mar;79(3):419-34. doi: 10.1093/genetics/79.3.419.
Abstract
In Neurospora crassa, the phosphate-metabolizing enzymes are made during phosphate starvation, but not under phosphate sufficiency. The synthesis of these enzymes is controlled by three regulatory genes: pcon-nuc-2, preg and nuc-1, pcon-nuc-2 and preg are closely linked. A model of the hierarchical relationships among these regulatory genes is presented. Studies of double mutants and revertants confirm several predictions of the model. It has been found that nuc-2 (null) and pcon-c (constitutive) mutations reside in the same cistron. preg-c (constitutive) mutations are epistatic to nuc-2 mutations. nuc-1 (null) mutations are epistatic to all others.
摘要
在粗糙脉孢菌中，磷酸盐代谢酶是在磷酸盐饥饿期间产生的，但在磷酸盐充足的情况下则不会产生。这些酶的合成受三个调控基因控制：pcon-nuc-2、preg和nuc-1，pcon-nuc-2和preg紧密连锁。本文提出了这些调控基因之间层次关系的模型。对双突变体和回复体的研究证实了该模型的几个预测。已发现nuc-2（无效）和pcon-c（组成型）突变位于同一顺反子中。preg-c（组成型）突变对nuc-2突变呈上位性。nuc-1（无效）突变对所有其他突变呈上位性。
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