Metzenberg R L, Gleason M K, Littlewood B S
Genetics. 1974 May;77(1):25-43. doi: 10.1093/genetics/77.1.25.
In wild-type Neurospora, alkaline phosphatase is made under conditions of phosphate limitation, but not conditions of phosphate sufficiency. Mutants at two unlinked loci, nuc-1 and nuc-2, do not make alkaline phosphatase under any conditions, while mutants at two quite closely linked loci, pcon and preg, make alkaline phosphatase even under conditions of phosphate sufficiency. pcon is extremely closely linked to nuc-2. nuc-2 and preg(c) (constitutive) mutants are recessive to their wild-type alleles in partial diploids as well as in heterokaryons, while pcon(c) mutants are dominant or co-dominant. nuc-1 is epistatic to both pcon(c) and preg(c) mutants. The implications of these findings for theories of metabolic control in eukaryotes are briefly discussed.
在野生型脉孢菌中，碱性磷酸酶在磷酸盐限制条件下产生，但在磷酸盐充足条件下则不产生。位于两个不连锁基因座（nuc - 1和nuc - 2）的突变体在任何条件下都不产生碱性磷酸酶，而位于两个紧密连锁基因座（pcon和preg）的突变体即使在磷酸盐充足条件下也能产生碱性磷酸酶。pcon与nuc - 2紧密连锁。nuc - 2和preg(c)（组成型）突变体在部分二倍体以及异核体中相对于其野生型等位基因是隐性的，而pcon(c)突变体是显性或共显性的。nuc - 1对pcon(c)和preg(c)突变体都是上位性的。本文简要讨论了这些发现对真核生物代谢控制理论的意义。
