Dupont S, Samson Y, Van de Moortele P-F, Samson S, Poline J-B, Hasboun D, Le Bihan D, Baulac M
CEA, SHFJ, Orsay, France.
J Neurol Neurosurg Psychiatry. 2002 Nov;73(5):478-85. doi: 10.1136/jnnp.73.5.478.
Functional MRI (fMRI ) was used to investigate right medial temporal lobe epilepsy (RTLE) effects on verbal memory.
BOLD fMRI data were collected from seven right sided MTLE patients (RTLE) and compared with the data previously acquired from seven left sided MTLE patients (LTLE) and 10 control subjects. Twenty two contiguous images covering the whole brain were acquired using an EPI echoplanar sequence. Subjects were instructed to learn a list of 17 words, and to recall it immediately and at 24 hours interval. Group analyses were performed using SPM96.
RTLE patients retrieval performances were significantly impaired as compared with the performance of control subjects. As compared with control subjects and LTLE patients, RTLE patients exhibited a different pattern of hemispheric activations and a global decrease in left hemisphere functional activity.
MTLE cannot be considered as a model of pure well lateralised hippocampal dysfunction. The verbal memory impairment depicted in RTLE patients may be considered as the witness of a bilateral impairment of the neuroanatomical circuits subserving memory.
运用功能磁共振成像（fMRI）研究右侧颞叶内侧癫痫（RTLE）对言语记忆的影响。
收集了7例右侧颞叶内侧癫痫患者（RTLE）的血氧水平依赖性功能磁共振成像（BOLD fMRI）数据，并与之前从7例左侧颞叶内侧癫痫患者（LTLE）和10例对照受试者获取的数据进行比较。使用EPI回波平面序列获取覆盖全脑的22幅连续图像。受试者被要求学习一组17个单词的列表，并在学习后立即及间隔24小时后进行回忆。使用SPM96进行组间分析。
与对照受试者的表现相比，RTLE患者的回忆表现明显受损。与对照受试者和LTLE患者相比，RTLE患者表现出不同的半球激活模式以及左半球功能活动的整体下降。
不能将颞叶内侧癫痫视为纯粹的、定位明确的海马功能障碍模型。RTLE患者中所描述的言语记忆损害可被视为支持记忆的神经解剖回路双侧受损的证据。
