Gunga H-C, Kirsch K, Beneke R, Böning D, Hopfenmüller W, Leithäuser R, Hütler M, Röcker L
Department of Physiology, Center of Space Medicine, Free University of Berlin, Clinical Center Benjamin Franklin, Berlin, Germany.
Int J Sports Med. 2002 Oct;23(7):495-9. doi: 10.1055/s-2002-35070.
It was the aim of the study to analyse the haemostatic system during a high standardized intensive short-term (30 s) exercise (anaerobic Wingate test). Blood samples were taken from 15 male subjects before (t0 ), and within 2 (t1 ), 9 (t2 ) and 30 min (t3 ) after the test. We found that the partial thromboplastin time was markedly shortened, whereas the prothrombin time increased slightly from t0 to t1 (p < 0.002) and remained elevated (t3, p < 0.046). Factor VIII increased from t0 to t1 (p < 0.001) and remained elevated as well (t3, p < 0.001). Fibrin monomers were approximately 15 times higher immediately post-exercise (t1, p < 0.001) and continued to be elevated (t3, p < 0.004). The tissue plasminogen activator increased by 4 times after exercise (t1, p < 0.001) and remained elevated (t3, p < 0.002). The d-dimers increased from t0 to t1 (p < 0.001) as well and remained elevated (t3, p < 0.005). Thrombopoietin concentrations were unchanged, whereas the vascular endothelial growth factor increased immediately post-exercise (t0 to t1, p < 0.011 resp. at t2 p < 0.019) and returned to the control level at t3 (p < 0.878). In conclusion, it was found that prothrombotic markers and, even more pronounced, those of the fibrinolytic system were increased. The study provides evidence that due to intensive short-term exercise the balance of the haemostatic system is shifted to a higher equilibrium. Theoretically, the data show that in the case of a subject with risk factors such as impaired fibrinolysis, unfavourable conditions cannot be excluded.
本研究旨在分析在高度标准化的短期（30秒）高强度运动（无氧温盖特试验）期间的止血系统。在测试前（t0）以及测试后2分钟（t1）、9分钟（t2）和30分钟（t3）从15名男性受试者采集血样。我们发现部分凝血活酶时间明显缩短，而凝血酶原时间从t0到t1略有增加（p<0.002）并持续升高（t3，p<0.046）。因子VIII从t0到t1增加（p<0.001）并同样持续升高（t3，p<0.001）。纤维蛋白单体在运动后即刻大约高出15倍（t1，p<0.001）并持续升高（t3，p<0.004）。组织纤溶酶原激活剂在运动后增加4倍（t1，p<0.001）并持续升高（t3，p<0.002）。D-二聚体也从t0到t1增加（p<0.001）并持续升高（t3，p<0.005）。血小板生成素浓度未改变，而血管内皮生长因子在运动后即刻增加（t0到t1，p<0.011；t2时p<0.019）并在t3时恢复到对照水平（p<0.878）。总之，发现促血栓形成标志物以及更明显的纤溶系统标志物增加。该研究提供了证据，表明由于短期高强度运动，止血系统的平衡向更高的平衡点转移。从理论上讲，数据表明，对于有诸如纤溶受损等危险因素的受试者，不能排除不利情况。
