Hamada Gerson Shigueaki, Kowalski Luiz Paulo, Nishimoto Inês Nobuko, Rodrigues Joaquim José Gama, Iriya Kiyoshi, Sasazuki Shizuka, Hanaoka Tomoyuki, Tsugane Shoichiro
Nikkei Disease Prevention Center, Santa Cruz Hospital, São Paulo, Brazil.
Jpn J Clin Oncol. 2002 Aug;32(8):284-90. doi: 10.1093/jjco/hyf061.
Although stomach cancer is the most frequent cancer among Japanese Brazilians, the risk factor of this cancer has not been investigated among them.
A case-control study was conducted among Japanese residents in the city of São Paulo. Ninety-six consecutive cases of histologically confirmed stomach cancer were matched to 192 controls admitted for non-neoplastic diseases or healthy volunteer (n = 80) by age (+/-5 years) and gender. The socio-demographic characteristics, personal and family medical history, lifetime history of tobacco use and dietary habits were probed using a structured questionnaire.
Frequent consumption of beef was associated with increased risk: odds ratio (OR) = 4.0 and 95% confidence interval (CI) = 1.9-8.4 for daily consumption, OR = 2.1 and 95% CI = 1.0-4.3 for 3-4 days/week) when compared with the category of lower consumption (<3 days/week) after adjustment for country of birth (Japan or Brazil), showing a dose-response pattern (P for trend = 0.001). These ORs became higher after further adjusted for fruit consumption: OR = 4.4, 95% CI = 2.1-9.4 and OR = 2.4 and 95% CI = 1.1-5.0, respectively. Daily consumption of fruit was associated with a reduction in risk (OR = 0.5, 95% CI = 0.3-1.0) after adjustment for country of birth and became statistically significant further adjusted for beef consumption (OR = 0.4, 95% CI = 0.2-0.9). There were no statistically significant associations with smoking or any other factors tested. Although some attenuation was observed in beef consumption, the observed associations were similar after excluding volunteer controls.
The introduction of the habit of daily beef consumption among Japanese immigrants and their descendants may be associated with stomach cancer risk. The protective effect of fruit consumption was confirmed in this population.
尽管胃癌是日裔巴西人中最常见的癌症，但尚未对该群体中这种癌症的风险因素进行调查。
在圣保罗市的日本居民中开展了一项病例对照研究。96例经组织学确诊的胃癌连续病例，按照年龄（±5岁）和性别与192名因非肿瘤性疾病入院的对照者或健康志愿者（n = 80）进行匹配。使用结构化问卷探究社会人口学特征、个人和家族病史、吸烟史以及饮食习惯。
频繁食用牛肉与风险增加相关：调整出生国家（日本或巴西）后，与低消费类别（每周<3天）相比，每日食用牛肉的比值比（OR）= 4.0，95%置信区间（CI）= 1.9 - 8.4；每周食用3 - 4天的OR = 2.1，95% CI = 1.0 - 4.3，呈现剂量反应模式（趋势P值 = 0.001）。进一步调整水果消费后，这些OR值更高：分别为OR = 4.4，95% CI = 2.1 - 9.4和OR = 2.4，95% CI = 1.1 - 5.0。调整出生国家后，每日食用水果与风险降低相关（OR = 0.5，95% CI = 0.3 - 1.0），进一步调整牛肉消费后具有统计学意义（OR = 0.4，95% CI = 0.2 - 0.9）。与吸烟或其他任何测试因素均无统计学显著关联。尽管在牛肉消费方面观察到一些减弱，但排除志愿者对照后，观察到的关联相似。
日本移民及其后代中引入每日食用牛肉的习惯可能与胃癌风险相关。在该人群中证实了水果消费的保护作用。
