Ramji Niranjan, Ramji Nivedita, Iyer Ritu, Chandrasekaran S
The Procter & Gamble Company, Health Care Research Center, 8700 Mason-Montgomery Road, Mason, OH 45040, USA.
J Ethnopharmacol. 2002 Nov;83(1-2):149-52. doi: 10.1016/s0378-8741(02)00194-0.
Piper betle L. (Piperaceae) leaves which are traditionally used in India and China in the prevention of oral malodor was examined by bioassay-guided fractionation to yield allylpyrocatechol (APC) as the major active principle which showed promising activity against obligate oral anaerobes responsible for halitosis. The biological studies with APC indicated that the potential to reduce methylmercaptan and hydrogen sulfide was mainly due to the anti-microbial activity as established using dynamic in vitro models.
蒌叶（胡椒科）叶在印度和中国传统上用于预防口腔异味，通过生物测定引导的分级分离进行研究，得到烯丙基邻苯二酚（APC）作为主要活性成分，该成分对导致口臭的专性口腔厌氧菌显示出有前景的活性。对APC的生物学研究表明，降低甲硫醇和硫化氢的潜力主要归因于使用动态体外模型确定的抗菌活性。
